Andrea Low

TL;DR: Though the mechanism remains obscure, the data suggest that there is either viral or immune-mediated accelerated T cell destruction or, possibly, alterations in T cell homing to the GI tract as the HIV-1–infected population survives longer owing to the benefits of HAART.

TL;DR: During acute and early human immunodeficiency virus type 1 (HIV-1) infection (AEI) more than 50% of CD4+ T cells are preferentially depleted from the gastrointestinal lamina propria, and ongoing infection of susceptible CD4- T cells, along with activation-induced cellular death and host cytotoxic cellular response, are responsible for the persistence of the lesion.

TL;DR: This meta-analysis provides strong evidence that opioid substitution therapy improves several key outcomes of the HIV care continuum among people who inject drugs, including recruitment onto antiretroviral therapy, retention in care, adherence, and viral suppression.

TL;DR: This meta-analysis provides strong evidence that antiretroviral therapy (ART) has led to a major reduction in the incidence of key opportunistic infections in low- and middle-income countries.

TL;DR: The integrase coding region contains as much natural variation as that seen in protease, but mutations associated with high-level resistance to existing InSTI are rarely, if ever, present in integrase naïve patients, especially those being used clinically.