Andrea N. Noyes

TL;DR: Applying assays of 59Fe-heme biosynthesis and colony numbers as measures of maturation and analyses of DNA degradation as an index of programmed cell death, it is found that erythropoietin (Epo) enhances maturation throughout most of its course and for maturation to be entirely optimal, an unidentified serum factor(s) is probably required when Epo levels are high and is certainly needed when EpO levels are like those in normal animals.

TL;DR: Although the early need for Epo by CFU-E is nearly absolute, this need is not met by the often substantial Epo already on board, suggesting that lingering low-affinity receptors may mediate some unrecognized Epo function.

TL;DR: The feasibility of differential hemolysis via NH4Cl--HCO3-mediated, acetazolamide- modulated reactions is shown by the successful isolation of the few fetal-origin erythrocytes present in grossly nonbloody amniotic fluids and by approximately 3300-fold enrichment of apparently authentic fetal- origin red cells from the arm blood of a woman in her 18th wk of pregnancy.

TL;DR: Comparisons of sequences suggest that δ and β genes in all primates either arose from a single event in a common ancestor or from two approximately coincident events.

TL;DR: A strong correlation emerges between the dosage of erythropoietin given and the degree of A → C switching observed, and this correlation is maintained despite the use of materials that originated in different species and had grossly different specific activities.