Showing papers in "Blood in 1989"

TL;DR: Human IL-6 (BSF2) was originally identified as a factor in the culture supernatants of mitogen or antigen-stimulated peripheral mononuclear cells, which induced immunoglobulin production in Epstein Barr virus transformed B-cell lines or in Staphylococcus aureus Cowan 1 stimulated normal B cells.

TL;DR: The CD14+/CD16+ cells appear to represent a new monocyte subset with a distinct functional repertoire and a survey of various tissues revealed that a large proportion of the alveolar macrophage, but not of the peritoneal macrophages, express the CD14-/ CD16+ phenotype.

TL;DR: Data demonstrated a paracrine but not autocrine regulation of the growth and differentiation of myeloma cells by IL-6, which is not the autocrine growth factor of these well-documented human myelomatic cell lines.

TL;DR: The findings in this report indicate that the generation of IL-6 by B cells in germinal centers of hyperplastic lymph nodes of Castleman's disease may be the key element responsible for the variety of clinical symptoms in this disease.

TL;DR: Levels of IL-6 on admission appeared to be of prognostic significance: levels were higher in septic patients who subsequently died than in those who survived, in particular when only patients with septic shock were considered.

TL;DR: The ability to purify these two populations independently shows that the LTC and clonogenic assays identify distinct, although not necessarily nonoverlapping cell types in human marrow.

TL;DR: RhIL-5 induced the greatest eosinophil production in liquid cultures, suggesting that although it may act on a smaller population of precursors, it is able to stimulate more proliferative steps than either rhIL-3 or rhGMCSF.

TL;DR: It is concluded that acute and chronic GVHD were associated with a durable antileukemic effect and improved survival in patients transplanted in advanced stages of ALL and CML.

TL;DR: In this paper, the influence of graft-versus-host disease (GVHD) on recurrent leukemia and survival after allogeneic marrow transplantation was investigated in 1,202 patients with acute nonlymphocytic leukemia (ANL), acute lymphocyte leukemia (ALL), and chronic myelogenous leukemia (CML) given unmodified marrow grafts from HLA-identical siblings.

TL;DR: In endothelial cells treated with secretagogues that stimulate vWf release the elongated structures positive for PADGEM disappeared, and this observation extends the parallels between Weibel-Palade bodies and alpha-granules and suggests a possible functional association between vWF and P ADGEM.

TL;DR: It is reported that hematopoietic progenitor cells expressing the CD34 antigen transiently circulate in the peripheral blood of cancer patients treated with 7 g/m2 cyclophosphamide (HD-CTX) with or without recombinant human granulocyte macrophage-colony stimulating factor (rHuGM-CSF).

TL;DR: The response to fludarabine was rapid, with 36 (92%) of the 39 responders having achieved at least a partial response following the first three courses, and complete responses occurred in the blood, liver, spleen, and lymph nodes in 48% to 69% of the patients.

TL;DR: Investigations show that a time-dependent cobblestone area formation exists that reflects the turnover time and primitiveness of CAFC, and is proposed to be a measure for MRA.

TL;DR: These regression models and the simpler scoring system may be accurately used for decision-making regarding therapy in MDS patients by demonstrating its capability of segregating patients into low-, intermediate-, and high-risk groups, with distinctively different survival curves.

TL;DR: Methotrexate/cyclosporine significantly reduced the incidence and severity of acute GVHD, and improved early survival, and did not interfere with sustained hematopoietic engraftment.

TL;DR: Interleukin-6 acts on maturational stages in megakaryocytopoiesis and promotes platelet production in vivo in mice, suggesting that IL-6 functions as thrombopoietin.

TL;DR: In situ hybridization revealed that in two HD cases, the EBV infected cells had the distinct morphology of Hodgkin and Reed-Sternberg cells, thus suggesting a direct pathoetiological relationship between EBV and some cases of HD.

TL;DR: This review summarizes the current understanding of the biochemical pathways of platelet activation and inhibition, with specific emphasis on recent advances and unresolved issues.

TL;DR: The neutrophil antigen responsible for the cytoplasmic staining pattern produced by autoantibodies in patients with active Wegener9s granulomatosis is a distinctive serine proteinase.

TL;DR: The results suggest that the sialic acid of the recombinant erythropoietin is necessary for this glycoprotein hormone to circulate stably and glycoproteins with more than three lactosaminyl repeat units may be cleared by the galactose binding protein of hepatocytes.

TL;DR: It was found that the G-CSF level rose during the neutropenic phase of cyclic neutropenia and after chemotherapy or bone marrow transplantation (BMT) in three patients with leukemia; also high G-SF levels were positively correlated to blood neutrophil counts in some cases of infectious disorders and lung cancer.

TL;DR: The in vivo lympholytic ability of CAMPATH-1G is very potent as compared with other monoclonal antibodies (MoAbs) and may have applications in therapy of lymphoid malignancies and as an immunosuppressive agent.

TL;DR: The diagnostic value of the Ber-H2 MoAb was most significant for a group of anaplastic large-cell lymphomas (ALC) lymphomas, of which more than 50 cases could be investigated, owing to applicability in paraffin sections.

TL;DR: The lack of a major advance in prognosis despite the use of more drugs and more intensive regimens justifies the continued use of standard melphalan-prednisone for patients with a highly favorable prognosis, for the very aged, and for those with a short life expectancy due to other major medical problems.

TL;DR: It is concluded that TNF induces the internalization and subsequent degradation of the TM molecule, and none of the components of the protein C anticoagulant pathway, either alone or in combination, prevented the TNF-dependent downregulation of TM antigen.

TL;DR: A comparison of normal and acatalasemic erythrocytes in the present study indicated that catalase accounts for more than half of the destruction of H2O2 when H 2O2 is generated at a rate comparable to that which leads to hemolysis in G6PD- deficient ery Throcytes.

TL;DR: It is concluded that hypersensitivity to the clastogenic effect of DEB is a useful discriminator for FA and a simplified scoring method for classifying patients on the basis of eight clinical manifestations that are the best predictors for FA is presented.

TL;DR: It is concluded that MDS arise from a multipotent hematopoietic stem cell with the potential for myeloid and lymphoid differentiation.

TL;DR: An attempt is made here to synthesize the information gained by studies of megakaryocytopoiesis in these various animal systems in order to develop unifying concepts that might be generally applicable to mammalian megakariespecies.