Showing papers in "Blood in 1976"

TL;DR: Compared to nontransplant regimens, early marrow transplantation more effectively restores normal marrow function and decreases the acute mortality of severe marrow aplasia.

TL;DR: The lupus-type anticoagulant, an inhibitor of the prothrombin activator complex, was demonstrated in 58 patients and was augmented in 67% of these patients by a cofactor present in normal plasma.

TL;DR: It is concluded that the accuracy of detecting iron deficiency in population surveys can be substantially improved by employing a battery of laboratory measurements of the iron status.

TL;DR: It is suggested that it may be practical to obtain an adequate number of stem cells from the peripheral blood to study autologous stem cell infusion as a means of averting myelosuppression in patients receiving intensive chemotherapy.

TL;DR: Bone marrow chromosomes obtained from 50 of 55 consecutive adult patients with acute nonlymphocytic leukemia were analyzed with quinacrine fluorescence and revealed the presence of nonrandom chromosome changes such as the addition of No. 8, the loss of No 7, and a gain or loss of one No. 21, which was very similar to that observed in patients with chronic myelogenous leukemia in the blast phase.

TL;DR: Results suggest that PMA activates the cell in the same manner as does phagocytosis, and this compound should provide a useful tool for elucidating the metabolic events underlying the phenomena of phagcytosis and bacterial killing by polymorphonuclear leukocytes.

TL;DR: The observation that anaerobic cells are incapable of generating O2- or reducing nitroblue tetrazolium (NBT) to formazan supports the idea that NBT reduction in phagocytizing PMN is due exclusively to oxygen-dependent O2 - generating oxidase which is deficient in chronic granulomatous disease leukocytes, despite their hyperphagocytic capacity.

TL;DR: The high frequency of this syndrome and the success in its control suggest that a controlled trial of prophylactic CNS therapy be instituted in patients with these histologic types of non-Hodgkin's lymphomas.

TL;DR: The long-term survival of 41% of the patients in the present study is similar to that achieved in the first 24 patients, and confirms the importance of marrow transplantation for the treatment of severe aplastic anemia.

TL;DR: Thalassemic erythrocytes contain more lipid per cell which is susceptible to peroxidation, and the distribution of fatty acids in these cells suggests that autooxidation of that lipid may have occurred.

TL;DR: It is confirmed that high levels are characteristic of thymus gland with both human and calf tissue and that elevated levels may be found in some cases of acute lymphocytic leukemia and that in chronic myelogenous leukemia in acute blast phase of the disease the proliferative blast response may not always be myeloblasts but inSome cases it may be lymphoblasts.

TL;DR: This augmented histogram resolution is an important codition for detecting small-degree numeric chromosomal aberrations and discrete drug perturbation effects.

TL;DR: The sedimentation velocity profiles of the entities in mouse bone marrow responsible for BFU-E and cfu-e and for erythrocytic colony formation have been studied under conditions designed to determine whether the values observed are real or result from cell interactions occurring during culture of the fractions.

TL;DR: The results suggest that the initial stimulus in response to acute thrombocytopenia acts primarily on diploid precursors, programming them to mature into a population of megakaryocytes with an average ploidy approximately one level greater than in normal rats and a proportionate increase in cell size.

TL;DR: Over the 4-yr period of study, single agent therapy has been associated with as good or better overall survival when compared to the more aggressive treatment programs (CVP and CVP-TLI).

TL;DR: It is concluded that granulocytes obtained by adherence to nylon fibers show both morphological and biochemical evidence of degranulation and diminished bactericidal capacity, and that these abnormalities may be causally related to decreased granulocyte survival in transfusion recipients.

TL;DR: The authors examined the morphological and functional characteristics of human marrow erythrocytes cultured with a recently developed methylcellulose colony assay technique and observed a significant degree of maturational synchrony within individual colonies.

TL;DR: Erythropoiesis during bone marrow recovery appears to be associated with an accelerated, albeit partial, recapitulation of ontogeny.

TL;DR: Observations support the concept that transferrin binds to a surface membrane receptor and is subsequently internalized by the developing red cell and time course and temperature dependence studies suggest the endocytosis of transferrin may be an important mechanism in delivery of iron to the developed red cell.

TL;DR: The data suggested that the patient's abnormal lymphoid cells may have interacted with the complement system to produce a biochemical defect and a clinical syndrome closely resembling angioedema of the hereditary type.

TL;DR: Investigating the ability of spleen lymphocytes isolated from Trichinella spiralis and Bacille Calmette Guerin infected mice to release colony-stimulating activity (CSA), a stimulator of granulopoiesis in vitro found it to be a result of specific antigen-lymphocyte interactions.

TL;DR: A virtually complete absence of glutathione reductase activity was found in the erythrocytes of all three children (one male, two females) from a consanguineous marriage and an abnormal oxygen consumption of the propositus' PMNs after phagocytosis of zymosan particles was found, suggesting that the glutathion reduct enzyme reaction was involved in the bactericidal capacity of these cells.

TL;DR: The neoplastic cells from seven patients with childhood lymphoblastic lymphoma were studied for cell surface markers and surface morphology in the scanning electron microscope and revealed clinical homogeneity in spite of the heterogeneous immunologic markers.

TL;DR: Application of this monocyte-mediated antibody-dependent cellular cytotoxicity assay to the study of patients with the Wiskott-Aldrich syndrome has revealed defective monocyte cytotoxic activity in spite of normal monocyte numbers, suggesting that this test may be useful for the assessment of monocyte function in a variety of clinical situations.

TL;DR: The patient's plasma contained an inhibitor which prevented aggregation of normal platelets by ristocetin, but which did not interfere with the measurement of VIIAGN or inactivate VIIAHF activity.

TL;DR: A simple device for maintaining PRP pH constant by control of the ambient pCO2 was designed and found effective in keeping both pH and quantitative ristocetin aggregation constant over a prolonged period of time.

TL;DR: A predictive model utilizing the in vitro result more accurately predicted for remission, both retrospectively and prospectively, than a model constructed with presently known prognostic parameters.

TL;DR: 5-Azacytidine administered by continuous infusion is well tolerated and is an active compound in acute myeloblastic leukemia.

TL;DR: Chromosome banding patterns were obtained for 50 of 55 consecutive adult patients with acute nonlymphocytic leukemia during a 5-yr period, and two cases of APL demonstrated a deletion of the long arm of No. 17 which occurred in the same region of the chromosome in each case.