Andrea Reyna

TL;DR: These studies provide compelling evidence for anxiolytic effects mediated by ERβ, and its neuroanatomical targets, that send or receive projections to/from the paraventricular nucleus, providing potential indirect mode of action for the control of hypothalamo-pituitary-adrenal axis function and behaviors.

TL;DR: It is demonstrated that antiprogestin, RU38486, was an effective inhibitor of PR-A-mediated, progesterone-dependent, but not SKF or 8-bromo-cAMP-dependent sexual receptivity, and the selective contributions of individual isoforms to the signaling pathways mediating female reproductive behavior are revealed.

TL;DR: E(2) regulation of mPRβ indicates a mechanism through which estrogens can regulate P(4) function within discrete brain regions to potentially impact behavior and demonstrate a wide distribution ofmPRβ in the rodent brain that may contribute to functions affecting behavioral, endocrine, motor, and sensory systems.

TL;DR: High-performance liquid chromatography analysis of ground corncob bedding extracts characterized two components that disrupted endocrine function in male and female rats and stimulated breast and prostate cancer cell proliferation in vitro and in vivo, suggesting that sex differences exist in response to these endocrine-disruptive agents.

TL;DR: Findings suggest that the THF-diols modulate hypothalamo-pituitary axis to regulate steroid hormone-dependent male sexual behavior.