U
Ulrich auf dem Keller
Researcher at Technical University of Denmark
Publications - 99
Citations - 5726
Ulrich auf dem Keller is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Proteases & Biology. The author has an hindex of 35, co-authored 79 publications receiving 4872 citations. Previous affiliations of Ulrich auf dem Keller include École Polytechnique Fédérale de Lausanne & ETH Zurich.
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Journal ArticleDOI
Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors
Yuanmei Lou,Paul C. McDonald,Arusha Oloumi,Stephen Chia,Christina Ostlund,Ardalan Ahmadi,Alastair H. Kyle,Ulrich auf dem Keller,Samuel Leung,David G. Huntsman,Blaise A. Clarke,Brent W. Sutherland,Dawn Waterhouse,Marcel B. Bally,Calvin D. Roskelley,Christopher M. Overall,Andrew I. Minchinton,Fabio Pacchiano,Fabrizio Carta,Andrea Scozzafava,Nadia Touisni,Jean-Yves Winum,Claudiu T. Supuran,Shoukat Dedhar +23 more
TL;DR: The findings show that CAIX is vital for growth and metastasis of hypoxic breast tumors and is a specific, targetable biomarker for breast cancer metastasis.
Journal ArticleDOI
Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products
Oded Kleifeld,Alain Doucet,Ulrich auf dem Keller,Anna Prudova,Oliver Schilling,Rajesh K. Kainthan,Amanda E. Starr,Leonard J. Foster,Jayachandran N. Kizhakkedathu,Christopher M. Overall +9 more
TL;DR: The approach, named terminal amine isotopic labeling of substrates (TAILS), addresses this challenge by using dendritic polyglycerol aldehyde polymers that remove tryptic and C-terminal peptides to discriminate between the substrates of the protease of interest and the products of background proteolysis.
Journal ArticleDOI
Nrf2 Transcription Factor, a Novel Target of Keratinocyte Growth Factor Action Which Regulates Gene Expression and Inflammation in the Healing Skin Wound
Susanne Braun,Christine Hanselmann,Marcus G. Gassmann,Ulrich auf dem Keller,Christiane Born-Berclaz,Kaimin Chan,Yuet Wai Kan,Yuet Wai Kan,Sabine Werner,Sabine Werner +9 more
TL;DR: The results reveal novel roles of the KGF-regulated transcription factors Nrf2 and possibly Nrf3 in the control of gene expression and inflammation during cutaneous wound repair.
Journal ArticleDOI
Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates
Oded Kleifeld,Oded Kleifeld,Alain Doucet,Anna Prudova,Ulrich auf dem Keller,Ulrich auf dem Keller,Magda Gioia,Magda Gioia,Jayachandran N. Kizhakkedathu,Christopher M. Overall +9 more
TL;DR: Step-by-step procedures for performing terminal amine isotopic labeling of substrates (TAILS) are described, a 2- to 3-d (depending on method of labeling) high-throughput method to identify and distinguish protease-generated neo–N termini from mature protein N termini with all natural modifications with high confidence.
Journal ArticleDOI
Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics
TL;DR: N-terminomics analyses using iTRAQ-TAILS links gelatinases with new mechanisms of action in angiogenesis and reveals unpredicted restrictions in substrate repertoires for these two very similar proteases.