S
Stephen Chia
Researcher at University of British Columbia
Publications - 283
Citations - 21126
Stephen Chia is an academic researcher from University of British Columbia. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 59, co-authored 250 publications receiving 17665 citations. Previous affiliations of Stephen Chia include BC Cancer Agency & University of Erlangen-Nuremberg.
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Journal ArticleDOI
Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer
Maggie C.U. Cheang,Stephen Chia,David Voduc,Dongxia Gao,Samuel Leung,Jacqueline E. Snider,Mark A. Watson,Sherri R. Davies,Philip S. Bernard,Joel S. Parker,Charles M. Perou,Matthew J. Ellis,Torsten O. Nielsen +12 more
TL;DR: Luminal B and luminal–HER2-positive breast cancers were statistically significantly associated with poor breast cancer recurrence-free and disease-specific survival in all adjuvant systemic treatment categories.
Journal ArticleDOI
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
Sohrab P. Shah,Andrew Roth,Rodrigo Goya,Arusha Oloumi,Gavin Ha,Yongjun Zhao,Gulisa Turashvili,Jiarui Ding,Kane Tse,Gholamreza Haffari,Ali Bashashati,Leah M Prentice,Jaswinder Khattra,Angela Burleigh,Damian Yap,Virginie Bernard,Andrew McPherson,Karey Shumansky,Anamaria Crisan,Ryan Giuliany,Alireza Heravi-Moussavi,Jamie Rosner,Daniel Lai,Inanc Birol,Richard Varhol,Angela Tam,Noreen Dhalla,Thomas Zeng,Kevin C. Ma,Simon K. Chan,Malachi Griffith,Annie Moradian,S.-W. Grace Cheng,Gregg B. Morin,Peter H. Watson,Karen A. Gelmon,Stephen Chia,Suet-Feung Chin,Christina Curtis,Christina Curtis,Oscar M. Rueda,Paul D.P. Pharoah,Sambasivarao Damaraju,John R. Mackey,Kelly Hoon,Timothy T. Harkins,Vasisht Tadigotla,Mahvash Sigaroudinia,Philippe Gascard,Thea D. Tlsty,Joseph F. Costello,Irmtraud M. Meyer,Connie J. Eaves,Wyeth W. Wasserman,Steven J.M. Jones,Steven J.M. Jones,David G. Huntsman,David G. Huntsman,Martin Hirst,Carlos Caldas,Marco A. Marra,Samuel Aparicio +61 more
TL;DR: It is shown that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes, and for the first time in an epithelial tumour subtype, the relative abundance of clonal frequencies among cases representative of the population is determined.
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Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype.
Maggie C.U. Cheang,David Voduc,Chris Bajdik,Samuel Leung,Steven McKinney,Stephen Chia,Charles M. Perou,Torsten O. Nielsen +7 more
TL;DR: The expanded surrogate immunopanel of estrogen receptor, progesterone receptor, human HER-2, EGFR, and cytokeratin 5/6 provides a more specific definition of basal-like breast cancer that better predicts breast cancer survival.
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Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer: a randomized phase II cardiac safety study (TRYPHAENA)
Andreas Schneeweiss,Stephen Chia,Tamas Hickish,Vernon Harvey,Alexandru Eniu,Roberto Hegg,C. Tausch,J.H. Seo,Y.-F. Tsai,Jayantha Ratnayake,V. McNally,Graham Ross,Javier Cortes +12 more
TL;DR: The combination of P with H and standard chemotherapy resulted in low rates of symptomatic LVSD, and the tolerability of H and P with chemotherapy in the neoadjuvant treatment of HER2-positive early breast cancer was assessed.
Journal ArticleDOI
Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors
Yuanmei Lou,Paul C. McDonald,Arusha Oloumi,Stephen Chia,Christina Ostlund,Ardalan Ahmadi,Alastair H. Kyle,Ulrich auf dem Keller,Samuel Leung,David G. Huntsman,Blaise A. Clarke,Brent W. Sutherland,Dawn Waterhouse,Marcel B. Bally,Calvin D. Roskelley,Christopher M. Overall,Andrew I. Minchinton,Fabio Pacchiano,Fabrizio Carta,Andrea Scozzafava,Nadia Touisni,Jean-Yves Winum,Claudiu T. Supuran,Shoukat Dedhar +23 more
TL;DR: The findings show that CAIX is vital for growth and metastasis of hypoxic breast tumors and is a specific, targetable biomarker for breast cancer metastasis.