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Andrea Testa
Researcher at University of Dundee
Publications - 39
Citations - 2050
Andrea Testa is an academic researcher from University of Dundee. The author has contributed to research in topics: Protein degradation & Ubiquitin ligase. The author has an hindex of 14, co-authored 37 publications receiving 1180 citations. Previous affiliations of Andrea Testa include University of Milan & University of Aberdeen.
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Journal ArticleDOI
Structural basis of PROTAC cooperative recognition for selective protein degradation.
M.S. Gadd,Andrea Testa,Xavier Lucas,Kwok-Ho Chan,Wenzhang Chen,Douglas J. Lamont,Michael Zengerle,Alessio Ciulli +7 more
TL;DR: The results elucidate how PROTAC-induced de novo contacts dictate preferential recruitment of a target protein into a stable and cooperative complex with an E3 ligase for selective degradation.
Journal ArticleDOI
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7
Vittoria Zoppi,Vittoria Zoppi,Scott J. Hughes,Chiara Maniaci,Andrea Testa,Teresa Gmaschitz,Corinna Wieshofer,Manfred Koegl,Kristin M. Riching,Danette L. Daniels,Andrea Spallarossa,Alessio Ciulli +11 more
TL;DR: This work describes a probe-quality degrader for a ligase–target pair deemed unsuitable: the von Hippel–Lindau (VHL) and BRD9, a bromodomain-containing subunit of the SWI/SNF chromatin remodeling complex BAF.
Journal ArticleDOI
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
Chiara Maniaci,Scott J. Hughes,Andrea Testa,Wenzhang Chen,Douglas J. Lamont,Sonia Rocha,Dario R. Alessi,Roberto Romeo,Alessio Ciulli +8 more
TL;DR: Homo-PROTACs is described as an approach to dimerize an E3 ligase to trigger its suicide-type chemical knockdown inside cells and small molecules that can induce the homo-dimerization of E3 ubiquitin ligases and cause their proteasome-dependent degradation.
Journal ArticleDOI
Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds
TL;DR: This work exemplifies as a cautionary tale how a more potent inhibitor does not necessarily generate more potent PROTACs and underscores the key roles played by the conjugation.
Journal ArticleDOI
Structure-Based Design of a Macrocyclic PROTAC.
TL;DR: The design and synthesis of a macrocyclic PROTAC is reported by adding a cyclizing linker to the BET degrader MZ1 to support macrocyclization as an advantageous strategy to enhance PROTAC degradation potency and selectivity between homologous targets.