Andreas Bernsel

TL;DR: Using in vitro translation of a model protein in the presence of dog pancreas rough microsomes to analyse a large number of systematically designed hydrophobic segments, a quantitative analysis of the position-dependent contribution of all 20 amino acids to membrane insertion efficiency is presented.

TL;DR: Topcons as discussed by the authors is a web server for consensus prediction of membrane protein topology, which combines an arbitrary number of topology predictions into one consensus prediction and quantifies the reliability of the prediction based on the level of agreement between the underlying methods.

TL;DR: The analysis of the genome sequence of the fast growing Antarctica bacterium Pseudoalteromonas haloplanktis TAC125 finds that it copes with the increased solubility of oxygen at low temperature by multiplying dioxygen scavenging while deleting whole pathways producing reactive oxygen species.

TL;DR: Two simple topology-prediction methods using a recently published experimental scale of position-specific amino acid contributions to the free energy of membrane insertion that perform on a par with the current best statistics-based topology predictors are presented.

TL;DR: The objective of the SPOCTOPUS algorithm is to minimize false predictions of transmembrane regions as signal peptides and vice versa and it compares favorably with state-of-the-art methods for signal peptide and topology predictions.