Andreas Otto

TL;DR: Results indicate that inhibition of Glo1 by curcumin may result in non-tolerable levels of MGO and GSH, which, in turn, modulate various metabolic cellular pathways including depletion of cellular ATP and G SH content.

TL;DR: Evidence is provided that the anti-inflammatory action ofalpha-oxo-carbonic acid esters is mediated by inhibition of glyoxalases (Glo), cytosolic enzymes that catalyse the conversion of alpha-Oxo-aldehydes such as methylglyoxal (MGO) into the corresponding alpha-hydroxy acids using glutathione as a cofactor.

TL;DR: In this article, the surface of a lactate dehydrogenase (LDH) isoenzymes from different species was probed for the presence of metal chelate binding sites using Cu-iminodiacetate-pEG (Cu-IDA-PEG).

TL;DR: The affinity between transition metal chelates and metal-binding sites situated on the cell surface by partitioning in aqueous two-phase system composed of poly(ethylene glycol) and dextran and the influence of various effectors such as imidazole, sialic acid on immobilized metal ion affinity partitioning was examined.

TL;DR: Ingestion of proteinases was found to trigger the formation of intermediate forms of α2-macroglobulin displaying high affinity to TGF-β, and proteinase therapy may have beneficial effects in treatment of fibrosis and certain cancers accompanied by excessively high T GF-β concentrations.