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Klaus Huse
Researcher at Leibniz Association
Publications - 80
Citations - 6164
Klaus Huse is an academic researcher from Leibniz Association. The author has contributed to research in topics: Alternative splicing & Gene. The author has an hindex of 33, co-authored 78 publications receiving 5691 citations. Previous affiliations of Klaus Huse include Institute of Molecular Biotechnology.
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Journal ArticleDOI
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
Jochen Hampe,Andre Franke,Philip Rosenstiel,Philip Rosenstiel,Andreas Till,Markus Teuber,Klaus Huse,Mario Albrecht,Gabriele Mayr,Francisco M. De La Vega,Jason C Briggs,Simone Günther,Natalie J. Prescott,Clive M. Onnie,Robert Häsler,Bence Sipos,Ulrich R. Fölsch,Thomas Lengauer,Matthias Platzer,Christopher G. Mathew,Michael Krawczak,Stefan Schreiber +21 more
TL;DR: Data suggest that the underlying biological process may be specific to Crohn disease, and that marker rs2241880, a coding SNP (T300A), carries virtually all the disease risk exerted by the ATG16L1 locus.
Journal ArticleDOI
Sarcoidosis is associated with a truncating splice site mutation in BTNL2.
Ruta Valentonyte,Jochen Hampe,Klaus Huse,Philip Rosenstiel,Mario Albrecht,Annette Stenzel,Marion Nagy,Karoline I. Gaede,Andre Franke,Robert Haesler,Andreas Koch,Thomas Lengauer,Dirk Seegert,Norbert Reiling,Stefan Ehlers,Eberhard Schwinger,Matthias Platzer,Michael Krawczak,Joachim Müller-Quernheim,Manfred Schürmann,Stefan Schreiber +20 more
TL;DR: A systematic three-stage SNP scan of 16.4 Mb on chromosome 6p21 in as many as 947 independent cases of familial and sporadic sarcoidosis and found that a 15-kb segment of the gene butyrophilin-like 2 (BTNL2) was associated with the disease.
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A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
Stephan Buch,Felix Stickel,Eric Trepo,Michael J. Way,A Herrmann,Hans Dieter Nischalke,Mario Brosch,Jonas Rosendahl,Thomas Berg,Monika Ridinger,Marcella Rietschel,Andrew McQuillin,Josef Frank,Falk Kiefer,Stefan Schreiber,Wolfgang Lieb,Michael Soyka,Nasser Semmo,Elmar Aigner,Christian Datz,Renate Schmelz,Stefan Brückner,Sebastian Zeissig,Anna-Magdalena Stephan,Norbert Wodarz,Jacques Devière,Nicolas Clumeck,Christoph Sarrazin,Frank Lammert,Thierry Gustot,Pierre Deltenre,Pierre Deltenre,Henry Völzke,Markus M. Lerch,Julia Mayerle,Florian Eyer,Clemens Schafmayer,Sven Cichon,Markus M. Nöthen,Michael Nothnagel,David Ellinghaus,Klaus Huse,Andre Franke,Steffen Zopf,Claus Hellerbrand,Christophe Moreno,Denis Franchimont,Marsha Y. Morgan,Jochen Hampe +48 more
TL;DR: A genome-wide association study for alcohol-related cirrhosis in individuals of European descent with subsequent validation in two independent European cohorts is performed, suggesting that lipid turnover is important in the pathogenesis of alcohol- related Cirrhosis.
Journal ArticleDOI
Purification of antibodies by affinity chromatography.
TL;DR: The purification strategies for antibodies by interaction with affinity ligands such as antibodies and Fe receptors or low molecular weight compounds are described.
Journal ArticleDOI
Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations.
Peter J. P. Croucher,Silvia Mascheretti,Jochen Hampe,Klaus Huse,Henning Frenzel,Monika Stoll,Timothy T. Lu,Susanna Nikolaus,Suk-Kyun Yang,Michael Krawczak,Won Ho Kim,Stefan Schreiber +11 more
TL;DR: Examination of single nucleotide polymorphisms of the CARD15 (NOD2) gene in populations of north-European and Korean descent confirmed that the three disease-associated SNPs occur independently but share a common background haplotype, suggesting a common origin and the possibility of an undiscovered more strongly predisposing mutation.