T
Thomas S. Weiss
Researcher at University Hospital Regensburg
Publications - 190
Citations - 8542
Thomas S. Weiss is an academic researcher from University Hospital Regensburg. The author has contributed to research in topics: Liver regeneration & Fatty liver. The author has an hindex of 47, co-authored 181 publications receiving 7463 citations. Previous affiliations of Thomas S. Weiss include University of Regensburg & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Journal ArticleDOI
PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis
Marcus Mühlbauer,Martin Fleck,Christian Schütz,Thomas S. Weiss,Matthias Froh,Christian U. Blank,Jürgen Schölmerich,Claus Hellerbrand +7 more
TL;DR: A novel bidirectional interaction between hepatocytes and lymphocytes modulated by PD-L1 expression in hepatocytes is suggested, which may contribute to the unique immunological properties of the liver.
Journal ArticleDOI
GLUT1 Expression Is Increased in Hepatocellular Carcinoma and Promotes Tumorigenesis
T. Amann,Ulrike Maegdefrau,Arndt Hartmann,Abbas Agaimy,Jörg Marienhagen,Thomas S. Weiss,Oliver Stoeltzing,Christina Warnecke,Jürgen Schölmerich,Peter J. Oefner,Marina Kreutz,Anja-Katrin Bosserhoff,Claus Hellerbrand +12 more
TL;DR: It is suggested that increased GLUT1 expression levels in HCC cells functionally affect tumorigenicity, and thus,GLUT1 is proposed as an innovative therapeutic target for this highly aggressive tumor.
Journal ArticleDOI
Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells.
Hella Wobser,Christoph Dorn,Thomas S. Weiss,T. Amann,Cornelius Bollheimer,Roland Büttner,Jürgen Schölmerich,Claus Hellerbrand +7 more
TL;DR: In vitro data indicate a potential mechanism for the pathophysiological link between hepatic steatosis and fibrogenesis in vivo, and provide an attractive in vitro model to study the molecular mechanisms of steatotic-induced fibrogensesis, and to identify and test novel targets for antifibrotic therapies in fatty liver disease.
Journal ArticleDOI
A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease.
Marcus Mühlbauer,Anja K. Bosserhoff,Arndt Hartmann,Wolfgang E. Thasler,Thomas S. Weiss,Hans H Herfarth,Guntram Lock,Jürgen Schölmerich,Claus Hellerbrand +8 more
TL;DR: In Inheritance of the -2518 MCP-1 G allele, which appears to affect hepatic M CP-1 expression, may predispose HCV patients to more severe hepatic inflammation and fibrosis.