A
Andreas W. Flemmer
Researcher at Boston Children's Hospital
Publications - 98
Citations - 2142
Andreas W. Flemmer is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Lung. The author has an hindex of 17, co-authored 74 publications receiving 1770 citations. Previous affiliations of Andreas W. Flemmer include Royal Women's Hospital & Ludwig Maximilian University of Munich.
Papers
More filters
Journal ArticleDOI
Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
Michael S. D. Kormann,Günther Hasenpusch,Manish K. Aneja,Gabriela Nica,Andreas W. Flemmer,Susanne Herber-Jonat,Marceline Huppmann,Lauren Mays,Marta C Illenyi,Andrea Schams,Matthias Griese,Iris Bittmann,Rupert Handgretinger,Dominik Hartl,Joseph Rosenecker,Carsten Rudolph +15 more
TL;DR: In a mouse model of a lethal congenital lung disease caused by a lack of surfactant protein B (SP-B), twice weekly local application of an aerosol of modified SP-B mRNA to the lung restored 71% of the wild-type SP- B expression, and treated mice survived until the predetermined end of the study after 28 days.
Journal ArticleDOI
Targeted delivery of magnetic aerosol droplets to the lung
Petra Dames,Petra Dames,Bernhard Gleich,Andreas W. Flemmer,Kerstin Hajek,Nicole Seidl,Frank Wiekhorst,Dietmar Eberbeck,Iris Bittmann,Christian Bergemann,Thomas Weyh,Lutz Trahms,Joseph Rosenecker,Carsten Rudolph,Carsten Rudolph +14 more
TL;DR: It is shown theoretically by computer-aided simulation, and for the first time experimentally in mice, that targeted aerosol delivery to the lung can be achieved with aerosol droplets comprising superparamagnetic iron oxide nanoparticles—so-called nanomagnetosols—in combination with a target-directed magnetic gradient field.
Journal ArticleDOI
Antenatal prediction of lung volume and in-utero treatment by fetal endoscopic tracheal occlusion in severe isolated congenital diaphragmatic hernia.
TL;DR: The purpose of this review is to update current knowledge regarding predictive value of prenatal assessment in terms of neonatal survival and to discuss experimental evidence and clinical data regarding fetal tracheal occlusion.
Journal ArticleDOI
Laryngeal closure impedes non-invasive ventilation at birth
Jessica R. Crawshaw,Marcus J. Kitchen,Corinna Binder-Heschl,Marta Thio,Megan J. Wallace,Lauren T. Kerr,CC Roehr,Katie Lee,Genevieve Buckley,Peter G Davis,Andreas W. Flemmer,Arjan B. te Pas,Stuart B. Hooper +12 more
TL;DR: In this paper, phase contrast X-ray imaging was used to visualise laryngeal function in spontaneously breathing premature rabbits immediately after birth and at approximately 1 hour after birth to investigate whether closure of the larynx and epiglottis is a major site of airway obstruction.
Journal ArticleDOI
Ante-, peri- and postnatal factors associated with intraventricular hemorrhage in very premature infants.
Martin Poryo,Judith Caroline Boeckh,Ludwig Gortner,Michael Zemlin,Perrine Duppré,Daniel Ebrahimi-Fakhari,Stefan Wagenpfeil,Matthias Heckmann,Eva Mildenberger,Anne Hilgendorff,Andreas W. Flemmer,G. Frey,Sascha Meyer,Ngfn Nationales Genomforschungsnetz Deutschland +13 more
TL;DR: The comprehensive analysis demonstrated that the occurrence of IVH in very premature infants is significantly associated with ante-, peri- and postnatal factors being either related to the degree of immaturity or indicating a critical clinical course after birth.