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Andree Zibert
Researcher at University of Münster
Publications - 36
Citations - 614
Andree Zibert is an academic researcher from University of Münster. The author has contributed to research in topics: Transthyretin & Wilson's disease. The author has an hindex of 14, co-authored 36 publications receiving 439 citations.
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Journal ArticleDOI
Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis
Elena V. Polishchuk,Assunta Merolla,Josef Lichtmannegger,Alessia Romano,Alessia Indrieri,Ekaterina Y. Ilyechova,Mafalda Concilli,Rossella De Cegli,Roberta Crispino,Marta Mariniello,Raffaella Petruzzelli,Giusy Ranucci,Raffaele Iorio,Federico Pietrocola,Claudia Einer,Sabine Borchard,Andree Zibert,Hartmut Schmidt,Elia Di Schiavi,Ludmila V. Puchkova,Brunella Franco,Guido Kroemer,Hans Zischka,Roman S. Polishchuk +23 more
TL;DR: ATP7B-deficient hepatocytes, such as in those in patients with WD, activate autophagy in response to copper overload to prevent copper-induced apoptosis, and agents designed to activate this autophagic pathway might decrease copper toxicity in Patients with WD.
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Wilson disease mutation pattern with genotype-phenotype correlations from Western India: confirmation of p.C271* as a common Indian mutation and identification of 14 novel mutations.
Annu Aggarwal,Gursimran Chandhok,Theodor Todorov,Saloni Parekh,Sharada Tilve,Andree Zibert,Mohit Bhatt,Hartmut Schmidt +7 more
TL;DR: This study significantly adds to the emerging data from other parts of India suggesting that p.C271* may be the most frequent mutation across India, and may harbor a moderate to severely disabling phenotype with limited variability.
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Impact of rapamycin on liver regeneration
Daniel Palmes,Andree Zibert,Tymotheus B. Budny,Ralf Bahde,Evgeny Minin,Linus Kebschull,Jens Peter Hölzen,Hartmut Schmidt,Hans-Ullrich Spiegel +8 more
TL;DR: The effect of RAPA on liver repair, angiogenesis, and HSC activation is confined to the phase of active cell proliferation, and might allow further exploration of mTOR inhibitors in clinical situations that involve liver regeneration, and seems to have implications beyond immunosuppression.
Journal ArticleDOI
Gender and strain-specific differences in the development of steatosis in rats
Sandra Stöppeler,D. Palmes,M Fehr,Jens Peter Hölzen,Andree Zibert,Ramsi Siaj,H H-J Schmidt,H-U Spiegel,Ralf Bahde +8 more
TL;DR: Strain and gender served major roles in disease progression in Lewis and Sprague-Dawley rats, where females showed lower alkaline phosphatase, cholesterol, triglyceride and leptin levels and a more favourable low-density lipoprotein/high-density cholesterol ratio than males.
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Mutation-specific Fabry disease patient-derived cell model to evaluate the amenability to chaperone therapy
Malte Lenders,Franciska Stappers,Christoph Niemietz,Boris Schmitz,Michel Boutin,Paula Ballmaier,Andree Zibert,Hartmut Schmidt,Stefan-Martin Brand,Christiane Auray-Blais,Eva Brand +10 more
TL;DR: It is concluded that repeated AGAL activity measurements in patients’ white blood cells are mandatory to assess the in vivo amenability to migalastat.