Roberta Crispino

TL;DR: ATP7B-deficient hepatocytes, such as in those in patients with WD, activate autophagy in response to copper overload to prevent copper-induced apoptosis, and agents designed to activate this autophagic pathway might decrease copper toxicity in Patients with WD.

TL;DR: It is shown that administration of D‐Aspartate during remyelination improved motor coordination, accelerated myelin recovery, and significantly increased the number of small‐diameter myelinated axons, and that D‐ aspartate treatment may represent a novel strategy for promoting myelin Recovery.

TL;DR: It is demonstrated that cadmium toxicity causes significant degeneration and loss of organization at both macro and microscopic levels and that recovery of visual acuity is due to a regenerative process by Müller cells.

TL;DR: Findings reveal Tranilast, Telmisartan, and Amphotericin B as effective drugs that selectively promote cisplatin toxicity in Pt-resistant ovarian cancer cells and underscore the efficiency of HTS strategy for identification of biosafe compounds, which might be rapidly repurposed to overcome resistance of tumors to Pt-based chemotherapy.

TL;DR: The data reveal a fundamental role of GRASP65 in the integration of different stimuli to modulate Golgi structure and microtubule organization during cell division, and are in agreement with an important role, tubulin acetylation is strongly reduced during the G2 phase of the cell cycle, allowing the separation of the Golgi stacks.