Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis

TLDR: ATP7B-deficient hepatocytes, such as in those in patients with WD, activate autophagy in response to copper overload to prevent copper-induced apoptosis, and agents designed to activate this autophagic pathway might decrease copper toxicity in Patients with WD.

About: This article is published in Gastroenterology.The article was published on 2019-03-01 and is currently open access. It has received 124 citations till now. The article focuses on the topics: Copper toxicity & Autophagy.

Figures

Figure 4. Lack of ATP7B affects the ultrastructure and function of lysosomes.

Figure 7. Cu overload induces mitophagy in ATP7B-deficient cells.

Figure 1. ATP7B-deficient cells exhibit stronger activation of autophagy in response to

Table 9) were observed in Cu-treated ATP7B-ko cells. Usually, loss of membrane

Frequently asked questions

Q1. What are the contributions mentioned in the paper "Activation of autophagy, observed in liver tissues from patients with wilson disease and from atp7b-deficient animals, protects hepatocytes from copper-induced apoptosis" ?

In this paper, Polishchuk, Assunta Merolla, Josef Lichtmannegger, Alessia Romano, Mafalda Concilli, Rossella De Cegli, Roberta Crispino, Marta Mariniello, Raffaella Petruzzelli, Giusy Ranucci, Raffe Iorio, Federico Pietrocola, Claudia Einer, Sabine Borchard, Andree Zibert, Hartmut H. Schmidt, Elia Di Schiavi, Ludmila V. Puchk 

Q2. GOTERM_BP_FAT - RNA transport - RNA transport?

GO:0050658~RNA transport 39 SRSF1, NXT1, SRSF11, EIF5A, NUP188, NXT2, NDC1, HNRNPA3, CDC40, U2AF1, QKI, MRPL18, TNKS, NUP35, KHDRBS1, PABPN1, RPSA, NUP133, NUP153, RAN, NUP88, MAGOH, HNRNPA2B1, NUP85, RNPS1, SRSF2, EIF4A3, SRSF5, EIF4E, UPF3B, SRSF7, POLDIP3, SRSF9, EIF5AL1, RBMX2, KHSRP, NUTF2, NUP107, NUP430.09441085 GOTERM_BP_FAT 

Q3. regulation of cellular localization CHERP, CHMP3, PT?

GO:0060341~regulation of cellular localization 130 CHERP, CHMP3, IL18, PTPN23, SAE1, CCT2, FLCN, ERLEC1, CTNNB1, BAK1, MFF, GAB2, STARD7, GBF1, INSIG1, RALB, U2AF1, PRKACA, CDCA5, RAB21, EGFR, MCRS1, RINT1, PIM3, LYPLA1, GCC2, JUP, HES1, NPTN, VAMP3, GBP1, STX8, STX7, NFKBIA, KEAP1, NAPA, NAPB, SNX3, ZMYND8, ITGB1, UBAC2, UHMK1, SRC, PIN1, PSMB7, UBE2D3, PFN2, TOMM7, EMD, TFDP1, MAP2K1, MAP2K2, SYT11, ITGA3, UBE2L3, RNF103-CHMP3, EPHA2, CCT7, P2RX5, LAMP1, HDAC3, CDKN1A, CCT5, CCT4, BBC3, CCT8, NUTF2, RAP1B, PDCD5, ABL1, CREBRF, JPH2, LEPROTL1, PINK1, CLTC, PRDX1, NDUFAF2, CDC42, TRIM8, TMEM59, CASP8, RHOA, YOD1, VPS11, RHOG, AKT2, KHDRBS1, STX1A, STX4, STX3, ZDHHC8, ECT2, LDLRAP1, RAB11FIP5, CAPN10, DACT3, RAB5A, RANGRF, SNX12, LCP1, MED1, BID, PARD3, YWHAZ, PPP3R1, RDX, FKBP1A, ZBTB17, CALCA, MTMR2, PPP1R12A, BCL3, NEFH, FBXW11, RBM22, GDI1, NUP153, LMNA, SIRT1, YWHAE, RPL28, UBL5, SCFD1, RASSF5, GSK3A, GSK3B, BNIP3L, YWHAQ, JAK2, OGG10.13952667 GOTERM_BP_FAT 

Q4. establishment of protein localization 156 RPL18, SRP14?

GO:0045184~establishment of protein localization 156 RPL18, SRP14, RPL36A, CHMP5, IL18, RPL15, CHMP7, EIF5A, RAB1B, SAE1, ANKRD1, PMAIP1, SRP19, RAB1A, STARD7, RAE1, RPLP0, U2AF1, RPL10, MCOLN1, RPL11, RPS27A, GPR89A, AP5Z1, RPL35A, RAN, GOLT1B, C16ORF62, PIM3, LYPLA1, CD40, DDIT3, JUP, RBPMS, CCR7, KRT18, SEC61B, RPS16, RAB18, JUN, RPS15, RPS12, RPS13, SLU7, RPS10, PAEP, VPS26A, SEC61G, ZFAND6, SYVN1, MTX3, NFKBIA, ATP6V1B2, UBAC2, LLGL1, UBE2D3, PSMB7, TOMM7, RPS29, RPL7, RPL9, RPL10A, TRAF6, RPS21, EMD, RPS23, TFDP1, RPS24, FAM160A2, HERPUD1, IL1RL1, SYT11, SNAPIN, ITGA3, CD63, RNF103-CHMP3, ABCG1, RPS8, RPS7, CCT7, HDAC3, CCT4, RPL18A, CD58, CCT8, ARF4, NUTF2, RPL37A, MAFA, PDCD5, ATG16L2, ATP6V0E1, AP3S1, PIP5K1A, VGF, LRRC15, PRDX1, WBP2, AKR1C3, HSPH1, GOLGA7, TMEM59, IL4R, KLHL20, PSMD9, ZW10, STX1A, HSP90AA1, UFD1L, SLC25A5, ZDHHC8, MCU, ATP6V1H, ATP6V1D, NLRP1, TNFRSF9, RAB11FIP5, DACT3, ATG4A, EIF5AL1, KPNA7, RANGRF, SRP9, LCP1, CSF3, NXT1, TNFRSF21, RAB3B, SNX16, PPP3R1, TRIM16, ATP6V1G1, SFN, ZBTB17, NXT2, SFT2D1, POU2F2, HINFP, ZC3H12A, SEC22B, IN0.00258682 GOTERM_BP_FAT 

Q5. regulation of protein localization 134 CHERP, IL18, FLCN?

GO:0032880~regulation of protein localization 134 CHERP, IL18, SAE1, CCT2, FLCN, ERLEC1, CTNNB1, MFF, PICALM, STARD7, GBF1, RALB, U2AF1, PRKACA, SLC8B1, CDCA5, DNAJC1, EGFR, MCRS1, PIM3, LYPLA1, CD40, GCC2, JUP, HES1, RSL1D1, CCR7, NPTN, VAMP3, GBP1, HMGB1, STX8, STX7, NFKBIA, KEAP1, SNX3, ENSA, ZMYND8, ITGB1, UBAC2, UHMK1, SRC, PIN1, UBE2D3, PSMB7, TOMM7, TRAF6, EMD, ARHGDIA, TFDP1, RHBDF2, SYT11, CD276, NDFIP2, ITGA3, UBE2L3, EPHA2, CCT7, HDAC3, CDKN1A, CCT5, CCT4, HDAC1, BBC3, CD58, CCT8, NUTF2, DNAJB2, PDCD5, ABL1, CREBRF, SEC24A, LEPROTL1, PINK1, DPH3, CLTC, PRDX1, NDUFAF2, CDC42, TRIM8, TMEM59, CASP8, RHOA, YOD1, VPS11, RHOG, AKT2, PSMD9, STX1A, STX4, STX3, SLC25A5, ZDHHC8, MCU, ECT2, LDLRAP1, NLRP1, RAB11FIP5, CAPN10, DACT3, RANGRF, WASL, SNX12, PRNP, LCP1, MED1, BID, TNFRSF21, YWHAZ, PPP3R1, TRIM16, RDX, FKBP1A, ZBTB17, SUMO1, RAB11A, BCL3, FBXW11, RBM22, GDI1, TMBIM6, LMNA, SIRT1, YWHAE, RPL28, UBL5, SCFD1, RASSF5, GSK3A, GSK3B, BNIP3L, YWHAQ, JAK2, OGG19.90400607Annotation Cluster 44 Enrichment Score: 1.8701059089873502 Category Term Count Genes FDR GOTERM_BP_FAT