A
Assunta Merolla
Publications - 1
Citations - 124
Assunta Merolla is an academic researcher. The author has contributed to research in topics: TFEB & Autophagy-related protein 13. The author has an hindex of 1, co-authored 1 publications receiving 56 citations.
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Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis
Elena V. Polishchuk,Assunta Merolla,Josef Lichtmannegger,Alessia Romano,Alessia Indrieri,Ekaterina Y. Ilyechova,Mafalda Concilli,Rossella De Cegli,Roberta Crispino,Marta Mariniello,Raffaella Petruzzelli,Giusy Ranucci,Raffaele Iorio,Federico Pietrocola,Claudia Einer,Sabine Borchard,Andree Zibert,Hartmut Schmidt,Elia Di Schiavi,Ludmila V. Puchkova,Brunella Franco,Guido Kroemer,Hans Zischka,Roman S. Polishchuk +23 more
TL;DR: ATP7B-deficient hepatocytes, such as in those in patients with WD, activate autophagy in response to copper overload to prevent copper-induced apoptosis, and agents designed to activate this autophagic pathway might decrease copper toxicity in Patients with WD.