C
Claudia Einer
Researcher at Ludwig Maximilian University of Munich
Publications - 14
Citations - 924
Claudia Einer is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Mitochondrion & Copper toxicity. The author has an hindex of 8, co-authored 12 publications receiving 593 citations.
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Journal ArticleDOI
Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes
Monika Julia Wolf,Arlind Adili,Kira Piotrowitz,Zeinab Abdullah,Yannick Boege,Kerstin Stemmer,Marc Ringelhan,Nicole Simonavicius,Michèle Egger,Dirk Wohlleber,Anna Lorentzen,Claudia Einer,Sabine Schulz,Thomas Clavel,Ulrike Protzer,Christoph Thiele,Hans Zischka,Holger Moch,Matthias H. Tschöp,Alexei V. Tumanov,Dirk Haller,Kristian Unger,Michael Karin,Manfred Kopf,Percy A. Knolle,Achim Weber,Mathias Heikenwalder +26 more
TL;DR: A mouse model recapitulating key features of human metabolic syndrome, NASH, and HCC by long-term feeding of a choline-deficient high-fat diet is developed, demonstrating that distinct molecular mechanisms determine NASH and H CC development.
Journal ArticleDOI
Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis
Elena V. Polishchuk,Assunta Merolla,Josef Lichtmannegger,Alessia Romano,Alessia Indrieri,Ekaterina Y. Ilyechova,Mafalda Concilli,Rossella De Cegli,Roberta Crispino,Marta Mariniello,Raffaella Petruzzelli,Giusy Ranucci,Raffaele Iorio,Federico Pietrocola,Claudia Einer,Sabine Borchard,Andree Zibert,Hartmut Schmidt,Elia Di Schiavi,Ludmila V. Puchkova,Brunella Franco,Guido Kroemer,Hans Zischka,Roman S. Polishchuk +23 more
TL;DR: ATP7B-deficient hepatocytes, such as in those in patients with WD, activate autophagy in response to copper overload to prevent copper-induced apoptosis, and agents designed to activate this autophagic pathway might decrease copper toxicity in Patients with WD.
Journal ArticleDOI
Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival
Vladimir Chubanov,Silvia Ferioli,Annika Wisnowsky,David G. Simmons,Christin Leitzinger,Claudia Einer,Wenke Jonas,Yuriy Shymkiv,Harald Bartsch,Attila Braun,Banu Akdogan,Lorenz Mittermeier,Ludmila Sytik,Friedrich Torben,Vindi Jurinovic,Emiel P. C. van der Vorst,Christian Weber,Onder A. Yildirim,Karl Sotlar,Annette Schürmann,Susanna Zierler,Hans Zischka,Alexey G. Ryazanov,Alexey G. Ryazanov,Thomas Gudermann +24 more
TL;DR: It is shown that TRPM 6 activity in the placenta and yolk sac is essential for embryonic development and maintenance of organismal Mg2+ balance by TRPM6 is crucial for prenatal development and survival to adulthood.
Journal ArticleDOI
Mitochondrial copper homeostasis and its derailment in Wilson disease.
Hans Zischka,Claudia Einer +1 more
TL;DR: This work reviews mitochondrial copper homeostasis but also the impact of excessive mitochondrial copper in Wilson disease, a genetic disease characterized by dysfunctional copper excretion from the liver.
Journal ArticleDOI
A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease Rats
Claudia Einer,Christin Leitzinger,Josef Lichtmannegger,Carola Eberhagen,Tamara Rieder,Sabine Borchard,Ralf Wimmer,Gerald Denk,Bastian Popper,Frauke Neff,Elena V. Polishchuk,Roman S. Polishchuk,Stefanie M. Hauck,Christine von Toerne,Jennifer-Christin Müller,Uwe Karst,Bipin S. Baral,Alan A. DiSpirito,Andreas E. Kremer,Jeremy D. Semrau,Karl Heinz Weiss,Simon Hohenester,Hans Zischka +22 more
TL;DR: A high-calorie diet severely aggravates hepatic mitochondrial and hepatocellular damage in Wilson disease rats, causing an earlier onset of the disease and enhanced disease progression.