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Andrei O. Chertov
Researcher at University of Washington
Publications - 8
Citations - 476
Andrei O. Chertov is an academic researcher from University of Washington. The author has contributed to research in topics: Glutamate aspartate transporter & Mitochondrion. The author has an hindex of 8, co-authored 8 publications receiving 418 citations. Previous affiliations of Andrei O. Chertov include University of Maryland, College Park.
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Journal ArticleDOI
Flow of energy in the outer retina in darkness and in light
Jonathan D. Linton,Lars C. Holzhausen,Norbert Babai,Hongman Song,Kiyoharu J. Miyagishima,George W. Stearns,Ken J. Lindsay,J. Wei,Andrei O. Chertov,Theo A. Peters,Romeo Caffe,Helma Pluk,Mathias W. Seeliger,Naoyuki Tanimoto,Kimberly K. Fong,Laura Bolton,Denise L T Kuok,Ian R. Sweet,Theodore M. Bartoletti,Roxana A. Radu,Gabriel H. Travis,Willam N. Zagotta,Ellen Townes-Anderson,Edward D Parker,Catharina E.E.M. Van der Zee,Alapakkam P. Sampath,Maxim Sokolov,Wallace B. Thoreson,James B. Hurley +28 more
TL;DR: Vasculature of the tissue and the intracellular distribution of mitochondria can play key roles in setting the strategy for energy distribution in neurons and reveal how vascularization of neuronal tissue can influence the strategies neurons use for energy management.
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Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN
Li Wu,Arman Bashirova,Thomas D. Martin,Loreley Villamide,Erin Mehlhop,Andrei O. Chertov,Derya Unutmaz,Melissa Pope,Mary Carrington,Vineet N. KewalRamani +9 more
TL;DR: In this article, the rhesus macaque homolog for human DC-SIGN, a dendritic cell-specific C-type lectin, is described and characterized, showing that it preserves the virus transmission function of hu-DC-Sign, capturing and efficiently transducing simian and human immunodeficiency virus to target CD4+ T cells.
Journal ArticleDOI
Roles of Glucose in Photoreceptor Survival
Andrei O. Chertov,Lars C. Holzhausen,Iok Teng Kuok,Drew Couron,Edward D Parker,Jonathan D. Linton,Martin Sadilek,Ian R. Sweet,James B. Hurley +8 more
TL;DR: Mitochondrial activity and substrates for anabolic activity are required for photoreceptor survival and can enhance survival in mice deprived of glucose, and rapid and slow phases of cell death were identified.
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Inhibition of Mitochondrial Pyruvate Transport by Zaprinast Causes Massive Accumulation of Aspartate at the Expense of Glutamate in the Retina
Jianhai Du,Whitney M. Cleghorn,Laura Contreras,Ken J. Lindsay,Austin M. Rountree,Andrei O. Chertov,Sally J. Turner,Ayse Sahaboglu,Jonathan D. Linton,Martin Sadilek,Jorgina Satrústegui,Ian R. Sweet,François Paquet-Durand,James B. Hurley +13 more
TL;DR: The findings show that Zaprinast is a specific mitochondrial pyruvate carrier (MPC) inhibitor and may help to elucidate the roles of MPC in amino acid metabolism and hypoglycemia.
Journal ArticleDOI
Cytosolic reducing power preserves glutamate in retina
Jianhai Du,Whitney M. Cleghorn,Laura Contreras,Jonathan D. Linton,Guy C.-K. Chan,Andrei O. Chertov,Takeyori Saheki,Viren Govindaraju,Martin Sadilek,Jorgina Satrústegui,James B. Hurley +10 more
TL;DR: This report investigated how glutamate in a neural tissue is protected from catabolism, and found that retinas use activities of the malate aspartate shuttle to protect >98% of their glutamate from oxidation in mitochondria.