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Andrejs Ivanovs
Researcher at University of Edinburgh
Publications - 25
Citations - 962
Andrejs Ivanovs is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Stem cell & Population. The author has an hindex of 9, co-authored 22 publications receiving 762 citations. Previous affiliations of Andrejs Ivanovs include University of Glasgow & Uppsala University.
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Journal ArticleDOI
Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region
Stanislav Rybtsov,Malgorzata Sobiesiak,Samir Taoudi,Celine Souilhol,Jordi Senserrich,Anna Liakhovitskaia,Andrejs Ivanovs,Jon Frampton,Suling Zhao,Alexander Medvinsky +9 more
TL;DR: A CD45-negative population of pre-HSCs develops into definitive HSCs in the AGM region of the embryo.
Journal ArticleDOI
Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region
Andrejs Ivanovs,Stanislav Rybtsov,Lindsey Welch,Richard A. Anderson,Marc Turner,Marc Turner,Alexander Medvinsky +6 more
TL;DR: Human HSCs appear first in the embryonic dorsal aorta, and only later in the yolk sac, liver, and placenta; a single human AGM region HSC can generate at least 300 daughter H SCs that are retransplantable into secondary recipient mice.
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Human haematopoietic stem cell development: from the embryo to the dish
Andrejs Ivanovs,Stanislav Rybtsov,Elizabeth Ng,Elizabeth Ng,Edouard G. Stanley,Edouard G. Stanley,Edouard G. Stanley,Andrew G. Elefanty,Alexander Medvinsky +8 more
TL;DR: The extent to which in vitro differentiation of human pluripotent stem cells recapitulates bona fide human developmental haematopoiesis is discussed, and some future directions in the field are outlined.
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Concealed expansion of immature precursors underpins acute burst of adult HSC activity in foetal liver
TL;DR: A quantitative approach reveals how the pre-HSC pool undergoes dramatic growth in the aorta-gonad-mesonephros region and, by E11.5, reaches the size that matches the number of definitive HSCs in the E12.5 foetal liver.
Journal ArticleDOI
Identification of the Niche and Phenotype of the First Human Hematopoietic Stem Cells
Andrejs Ivanovs,Stanislav Rybtsov,Richard A. Anderson,Marc Turner,Marc Turner,Alexander Medvinsky +5 more
TL;DR: It is demonstrated that in the human embryo the first definitive HSCs also emerge asymmetrically and are localized to the AoV, which thus identifies a functional niche for developing human HSCS.