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Andrew G. Elefanty
Researcher at University of Melbourne
Publications - 186
Citations - 14197
Andrew G. Elefanty is an academic researcher from University of Melbourne. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 56, co-authored 169 publications receiving 12623 citations. Previous affiliations of Andrew G. Elefanty include Princess Margaret Hospital for Children & Royal Children's Hospital.
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Journal ArticleDOI
Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells to Cardiomyocytes: A Methods Overview
Christine L. Mummery,Jianhua Zhang,Elizabeth Ng,David A. Elliott,Andrew G. Elefanty,Timothy J. Kamp +5 more
TL;DR: A review of the basic biology underlying the differentiation of human pluripotent cells to cardiac lineages can be found in this paper, where the authors describe current state-of-the-art protocols, as well as ongoing refinements.
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Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney
Minoru Takasato,Pei Xuan Er,M. Becroft,Jessica M. Vanslambrouck,Edouard G. Stanley,Andrew G. Elefanty,Melissa H. Little +6 more
TL;DR: This study has successfully directed the differentiation of human embryonic stem cells (hESCs) through posterior primitive streak and IM under fully chemically defined monolayer culture conditions using growth factors used during normal embryogenesis, resulting in the synchronous induction of UB and MM that forms a self-organizing structure, including nephron formation, in vitro.
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SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells
Nicole Dubois,April M. Craft,Parveen Sharma,David A. Elliott,Edouard G. Stanley,Andrew G. Elefanty,Anthony O. Gramolini,Gordon Keller +7 more
TL;DR: This screen identified the signal-regulatory protein alpha (SIRPA) as a marker expressed specifically on cardiomyocytes derived from hESCs and human induced pluripotent stem cells (hiPSCs), and PECAM, THY1, PDGFRB and ITGA1 as markers of the nonmyocyte population.
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Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells
Asif M. Maroof,Sotirios Keros,Jennifer A. Tyson,Shui-Wang Ying,Yosif Ganat,Florian T. Merkle,Becky Liu,Adam L Goulburn,Edouard G. Stanley,Edouard G. Stanley,Andrew G. Elefanty,Andrew G. Elefanty,Hans Ruedi Widmer,Kevin Eggan,Peter A. Goldstein,Stewart A. Anderson,Stewart A. Anderson,Lorenz Studer +17 more
TL;DR: This study defines the signals sufficient for modeling human ventral forebrain development in vitro and lays the foundation for studying cortical interneuron involvement in human disease pathology.
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Functional Maturation of hPSC-Derived Forebrain Interneurons Requires an Extended Timeline and Mimics Human Neural Development
Cory R. Nicholas,Jiadong Chen,Yunshuo Tang,Derek G. Southwell,Nadine Chalmers,Daniel Vogt,Christine M Arnold,Ying-Jiun J. Chen,Edouard G. Stanley,Edouard G. Stanley,Andrew G. Elefanty,Andrew G. Elefanty,Yoshiki Sasai,Arturo Alvarez-Buylla,John L.R. Rubenstein,Arnold R. Kriegstein +15 more
TL;DR: It is found that early-stage progenitors progress via a radial glial-like stem cell enriched in the human fetal brain, and MGE-derived cortical interneuron deficiencies are implicated in a broad range of neurodevelopmental and degenerative disorders, highlighting the importance of these results for modeling human neural development and disease.