Andrew A. Brayman

TL;DR: This selective review of the biological effects of ultrasound presents a synopsis of the current understanding of how cells insonated in vitro are affected by inertial cavitation from the standpoint of physical and chemical mechanisms.

TL;DR: Observations of transient interactions among ultrasound, microbubbles, and microvessels provide insight into the mechanics of bubble-vessel interactions, which appear to depend qualitatively upon the mechanical properties of biological tissues.

TL;DR: Diagnostic ultrasound contrast agents have been developed for enhancing the echogenicity of blood and for delineating other structures of the body and their importance in the clinical setting remains uncertain.

TL;DR: Five specific hypotheses were tested in an in vivo rabbit auricular blood vessel model that acoustic cavitation nucleated by microbubble contrast agent can damage the endothelia of veins at relatively low spatial-peak temporal-average intensities and ultrasound/contrast agent-induced endothelial damage can be inherently thrombogenic, or can aid sclerotherapeuticThrombogenesis through the application of otherwise subtherapeutic doses of thromBogenic drugs.

TL;DR: The ultrasonic fragmentation thresholds of three specific UCAs, each with different shell and gas properties, were determined under various acoustic conditions and thick-shelled biSpheres had the highest fragmentation threshold and produced the lowest IC dose.