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Andrew Collins
Researcher at University of Oslo
Publications - 733
Citations - 44066
Andrew Collins is an academic researcher from University of Oslo. The author has contributed to research in topics: Comet assay & DNA damage. The author has an hindex of 100, co-authored 684 publications receiving 40634 citations. Previous affiliations of Andrew Collins include Norwegian University of Life Sciences & Pontifical Xavierian University.
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Age-related increases in human lymphocyte DNA damage: is there a role of aerobic fitness?
TL;DR: The results showed that younger subjects have lower DNA strand breaks and higher V�' O2max compared with older subjects and FPG‐sensitive sites are positively related with V˙ O2 max, probably as transient damage due to the acute effects of daily physical activity.
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Commercial chicken breeds exhibit highly divergent patterns of linkage disequilibrium
Reuben J. Pengelly,Almas Gheyas,Richard Kuo,Enrico Mossotto,Eleanor G. Seaby,David W. Burt,Sarah Ennis,Andrew Collins +7 more
TL;DR: The Malécot-Morton model of LD is applied to create additive LD maps that describe the high-resolution LD landscape of commercial chickens, showing minimal concordance between breeds of fine-scale LD patterns and the mechanisms underlying highly divergent LD patterns found in commercial chickens.
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Understanding the disease genome: gene essentiality and the interplay of selection, recombination and mutation
TL;DR: The case for using gene-specific measures to guide filtering of sequenced genomes seems strong, considering alongside additional distinctive properties of the disease genome, such as the timing of the evolutionary emergence of genes and the roles of their products in protein networks.
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Functional evaluation of DNA repair in human biopsies and their relation to other cellular biomarkers
TL;DR: Evaluating BER and NER activities in extracts from deep-frozen colon biopsies using an upgraded version of the in vitro comet-based DNA repair assay shows that measuring DNA repair activity is not easily replaceable by genomic or transcriptomic approaches, but should be applied with the latter techniques in a complementary manner.
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DNA repair after X-irradiation: lessons from plants
John Einset,Andrew Collins +1 more
TL;DR: Using Arabidopsis mutants homozygous for both ATM and BRCA1, it is found that both of these genes are required for DNA repair during the 3-h period of the authors' experiments, indicating that the 'slow' phase involves a homologous repair (HR) of double-strand breaks and clustered single- Strand breaks.