Andrew Collins

TL;DR: The ESCODD consortium of mainly European laboratories has attempted to minimize this artifact and to provide standard, reliable protocols for sample preparation and analysis as mentioned in this paper. But the accuracy of low levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) in DNA is hampered by the ease with which guanine is oxidized during preparation of DNA for analysis.

TL;DR: The comet assay has been modified to detect various base alterations, by including digestion of nucleoids with a lesion-specific endonuclease, and modifications to measure cellular antioxidant status and different types of DNA repair.

TL;DR: The results suggest that multiple-megabase-scale ancestral haplotypes persist in outbred human populations in broad genomic regions which have lower than average recombination rates.

TL;DR: It is reported here that JAK2V617F-associated disease is strongly associated with a specific constitutional Jak2 haplotype, designated 46/1, in all three disease entities compared to healthy controls and provides a model whereby a constitutional genetic factor is associated with an increased risk of acquiring a specific somatic mutation.

TL;DR: It seems that efficient antioxidant defences together with DNA repair maintain a steady‐state level of damage representing minimal risk to cell or organism.