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Andrew Deonarine
Researcher at Laboratory of Molecular Biology
Publications - 9
Citations - 1814
Andrew Deonarine is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Fibroblast activation protein, alpha & Web application. The author has an hindex of 5, co-authored 7 publications receiving 1356 citations.
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Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.
Christine Feig,James O. Jones,Matthew Kraman,Richard J.B. Wells,Andrew Deonarine,Derek S. Chan,Claire M. Connell,Edward W. Roberts,Qi Zhao,Otavia L. Caballero,Sarah A. Teichmann,Tobias Janowitz,Duncan I. Jodrell,David A. Tuveson,Douglas T. Fearon +14 more
TL;DR: A single protein, CXCL12, from a single stromal cell type, the FAP+ CAF, may direct tumor immune evasion in a model of human PDA, which permitted the analysis of why immunotherapy is ineffective in this human disease.
Journal ArticleDOI
Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
Edward W. Roberts,Andrew Deonarine,James O. Jones,Alice E. Denton,Christine Feig,Scott K. Lyons,Marion Espéli,Matthew Kraman,Brendan McKenna,Richard J.B. Wells,Qi Zhao,Otavia L. Caballero,Rachel Larder,Anthony P. Coll,Stephen O'Rahilly,Kevin M. Brindle,Sarah A. Teichmann,David A. Tuveson,Douglas T. Fearon +18 more
TL;DR: Ablation of stromal cells expressing fibroblast activation protein-α (FAP) results in cachexia and anemia, and loss of these cells is seen in transplantable tumor models.
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An atlas of mouse CD4+ T cell transcriptomes
Michael J. T. Stubbington,Bidesh Mahata,Bidesh Mahata,Valentine Svensson,Andrew Deonarine,Jesper K. Nissen,Alexander G. Betz,Sarah A. Teichmann,Sarah A. Teichmann +8 more
TL;DR: It is shown that hundreds of genes are regulated purely by alternative splicing to extend the knowledge of the role of post-transcriptional regulation in cell differentiation and provide a valuable resource for the study of CD4+ T cell populations.
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Duel of the fates: the role of transcriptional circuits and noise in CD4+ cells.
TL;DR: CD4+ T cells play key roles in orchestrating adaptive immune responses, and are a popular model for mammalian cell differentiation, and the relationship between noise, transcriptional circuits and epigenetic modifications in a variety of cell types is provided.
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Malaria-attributed death rates in India
TL;DR: Higher estimates of annual malaria deaths in India are reported and ascertaining proportional mortality attributable to malaria by use of verbal autopsy in areas of low malaria transmission has substantial limitations and the estimates of malaria mortality generated by this method should be interpreted with caution.