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Claire M. Connell
Researcher at University of Cambridge
Publications - 20
Citations - 2196
Claire M. Connell is an academic researcher from University of Cambridge. The author has contributed to research in topics: Cancer & Oncolytic adenovirus. The author has an hindex of 11, co-authored 17 publications receiving 1558 citations. Previous affiliations of Claire M. Connell include Cambridge University Hospitals NHS Foundation Trust & Queen Mary University of London.
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Journal ArticleDOI
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.
Christine Feig,James O. Jones,Matthew Kraman,Richard J.B. Wells,Andrew Deonarine,Derek S. Chan,Claire M. Connell,Edward W. Roberts,Qi Zhao,Otavia L. Caballero,Sarah A. Teichmann,Tobias Janowitz,Duncan I. Jodrell,David A. Tuveson,Douglas T. Fearon +14 more
TL;DR: A single protein, CXCL12, from a single stromal cell type, the FAP+ CAF, may direct tumor immune evasion in a model of human PDA, which permitted the analysis of why immunotherapy is ineffective in this human disease.
Journal ArticleDOI
Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity.
Thomas R. Flint,Tobias Janowitz,Claire M. Connell,Edward W. Roberts,Alice E. Denton,Anthony P. Coll,Duncan I. Jodrell,Douglas T. Fearon,Douglas T. Fearon,Douglas T. Fearon +9 more
TL;DR: Tumor-induced IL-6 impairs the ketogenic response to reduced caloric intake, resulting in a systemic metabolic stress response that blocks anti-cancer immunotherapy.
Journal ArticleDOI
CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response
Daniele Biasci,Martin Smoragiewicz,Claire M. Connell,Claire M. Connell,Zhikai Wang,Ya Gao,James Thaventhiran,Bristi Basu,Bristi Basu,Lukasz Magiera,T. Isaac Johnson,Lisa Bax,Aarthi Gopinathan,Christopher Isherwood,Ferdia A. Gallagher,Maria Pawula,Irena Hudecova,Davina Gale,Nitzan Rosenfeld,Petros Barmpounakis,Elizabeta C. Popa,Rebecca Brais,Edmund Godfrey,Fraz Mir,Frances M. Richards,Douglas T. Fearon,Douglas T. Fearon,Douglas T. Fearon,Tobias Janowitz,Duncan I. Jodrell +29 more
TL;DR: In this article, the authors showed that CXCL12-stimulated CXCR4 inhibits the directed migration mediated by all of the immune cell types that participate in an integrated immune response.
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Activating HER2 mutations as emerging targets in multiple solid cancers.
TL;DR: The heterogeneity of HER2 mutations in human cancers is highlighted, differences in the clinical efficacy of Her2-directed drugs between cancer types and possible mechanisms of primary and acquired resistance are highlighted in order to guide clinical practice and future drug development.
Journal ArticleDOI
Medical student perceptions of research and research-orientated careers: An international questionnaire study.
TL;DR: Great effort is needed to engage female students who report more significant barriers and less desire to follow research-orientated careers, and programmes designed to engage students with research should focus on overcoming identified barriers.