A
Andrew G. Gianoukakis
Researcher at University of California, Los Angeles
Publications - 63
Citations - 3183
Andrew G. Gianoukakis is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Thyroid cancer & Lenvatinib. The author has an hindex of 22, co-authored 56 publications receiving 2509 citations. Previous affiliations of Andrew G. Gianoukakis include UCLA Medical Center & Los Angeles Biomedical Research Institute.
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Journal ArticleDOI
Lenvatinib versus placebo in radioiodine-refractory thyroid cancer.
Martin Schlumberger,Makoto Tahara,Lori J. Wirth,Bruce G. Robinson,Marcia S. Brose,Rossella Elisei,Mouhammed Amir Habra,Kate Newbold,Manisha H. Shah,Ana O. Hoff,Andrew G. Gianoukakis,Naomi Kiyota,Matthew H. Taylor,Sung Bae Kim,Monika K. Krzyzanowska,Corina E. Dutcus,B.D.L. Heras,J. Zhu,Steven I. Sherman +18 more
TL;DR: Lenvatinib, as compared with placebo, was associated with significant improvements in progression-free survival and the response rate among patients with iodine-131-refractory thyroid cancer.
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Evidence for an Association between Thyroid-Stimulating Hormone and Insulin-Like Growth Factor 1 Receptors: A Tale of Two Antigens Implicated in Graves’ Disease
Shanli Tsui,Vibha Naik,Neil Hoa,Catherine J. Hwang,Nikoo F. Afifiyan,Amiya P. Sinha Hikim,Andrew G. Gianoukakis,Andrew G. Gianoukakis,Raymond S. Douglas,Raymond S. Douglas,Terry J. Smith +10 more
TL;DR: It is suggested that IGF-1R might mediate some TSH-provoked signaling and that this receptor associates with IGF- 1R in situ and together may comprise a functional complex in thyroid and orbital tissue.
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Increased Generation of Fibrocytes in Thyroid-Associated Ophthalmopathy
Raymond S. Douglas,Nikoo F. Afifiyan,Catherine J. Hwang,Kelvin K.L. Chong,Uzma Haider,Patrick Richards,Andrew G. Gianoukakis,Terry J. Smith +7 more
TL;DR: The findings suggest that fibrocytes may participate in the pathogenesis of TAO because they express relevant autoantigens such as IGF-I receptor and functional TSHR and differentially accumulate in orbital tissue in TAO.
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Aberrant expression of the insulin-like growth factor-1 receptor by T cells from patients with Graves' disease may carry functional consequences for disease pathogenesis.
Raymond S. Douglas,Andrew G. Gianoukakis,Andrew G. Gianoukakis,Shweta Kamat,Terry J. Smith,Terry J. Smith,Terry J. Smith +6 more
TL;DR: A potential role for IGF-1R displayed by lymphocytes in supporting the expansion of memory T cells in GD is suggested, as a disproportionately large fraction of peripheral blood T cells express IGF- 1R (CD3+IGF-R+).
Journal ArticleDOI
Cytokines, Graves' disease, and thyroid-associated ophthalmopathy.
TL;DR: Interruption of chemoattractant cytokines elaborated by resident cells in the thyroid and orbit may provoke mononuclear cell infiltration and drive cell activation and tissue remodeling in Graves' disease and its orbital manifestations.