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Andrew J. Caton
Researcher at Wistar Institute
Publications - 110
Citations - 8822
Andrew J. Caton is an academic researcher from Wistar Institute. The author has contributed to research in topics: T-cell receptor & Antigen. The author has an hindex of 44, co-authored 110 publications receiving 8564 citations. Previous affiliations of Andrew J. Caton include University of Pennsylvania & University of Oxford.
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Journal ArticleDOI
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide.
Martha S. Jordan,Alina Boesteanu,Amy J. Reed,Andria L. Petrone,Andrea E. Holenbeck,Melissa A. Lerman,Ali Naji,Andrew J. Caton +7 more
TL;DR: It is shown that interactions with a single self-peptide can induce thymocytes that bear an autoreactive T cell receptor (TCR) to undergo selection to become CD4+CD25+ regulatory T cells.
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The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype).
TL;DR: An operational antigenic map of the hemagglutinin of influenza virus A/PR/8/34 indicates the presence of five immunodominant antigenic regions exhibiting various degrees of operational linkage.
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Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells
TL;DR: It is found that CD4+25+ T cells are present in the thymus and periphery of K14-Aβ b and H2-DMα–deficient mice and, like their wild-type counterparts, suppress the proliferation of cocultured CD4-25− effector T cells.
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Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes.
Masao Yamada,Robert Wasserman,Betty Anne Reichard,Sara Shane,Andrew J. Caton,Giovanni Rovera +5 more
TL;DR: Eight sequences that have a DN1-like D sequence with two base changes at the same positions were identified, suggesting the likely existence of a new germ line D gene belonging to the DN families.
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A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity
Bernadette Scott,Roland S. Liblau,Sylvia Degermann,Lori Anne Marconi,Lynn Ogata,Andrew J. Caton,Hugh O. McDevitt,David Lo +7 more
TL;DR: T cells from resistant double transgenic mice showed evidence for prior activation by antigen, suggesting that disease may be actively suppressed by autoreactive Th2 cells, shedding light on functional aspects of genetically determined susceptibility to autoimmunity.