Roland S. Liblau

TL;DR: The thesis that a particular subset of CD4+ T cells, namely T helper 1 (Th1) cells, contributes to the pathogenesis of organ-specific autoimmune diseases, while another subset, Th2 cells, prevents them is explored.

TL;DR: The results indicate that the spontaneous response to β-cell antigens arises very early in life and that the anti-GAD immune response has a critical role in the disease process during this period.

TL;DR: The results reveal the existence of a cycling Treg subset composed of autoreactive Treg that are continuously activated by tissue self-antigens.

TL;DR: Assessment of the proliferation, migration, and differentiation potential of adult SVZ progenitor cells in response to experimental autoimmune encephalomyelitis in mice indicates that the adult mouse SVZ is a source of newly generated oligodendrocytes and thus may contribute to the replacement of oligodends in inflammatory demyelinating diseases of the central nervous system such as multiple sclerosis.

TL;DR: Ito cells are identified as professional intrahepatic APCs activating T cells and eliciting a multitude of T cell responses specific for protein and lipid antigens.