Andrew J. Haak

TL;DR: It is demonstrated that early-intervention suicide-gene-mediated senescent cell ablation improves pulmonary function and physical health, although lung fibrosis is visibly unaltered, and fibrotic lung disease is mediated, in part, by senescent cells.

TL;DR: It is found that the Gαs-coupled dopamine receptor D1 (DRD1) is preferentially expressed in lung and liver mesenchymal cells relative to other resident cells of these organs, establishing a pharmacologically tractable and cell-selective approach to targeting YAP/TAZ via DRD1 that reverses fibrosis in mice.

TL;DR: Age-related changes in tissue mechanical properties that likely contribute to impaired lung function with aging are demonstrated and the potential to identify mechanisms that contribute to mechanical tissue remodeling through the study of human cells and tissues from across the aging spectrum is underscored.

TL;DR: The contexts in which senescent cells mediate wound healing and fibrotic pathology are reviewed and the potential utility of senotherapeutic drugs for treatment of Fibrotic disease is reviewed.

TL;DR: It is found that PGC1α levels are stably repressed in IPF fibroblasts, identifying P GC1α as an important regulator of the fibroblast’s pathological state in IPf.