Daniel L. Mazula

TL;DR: It is demonstrated that early-intervention suicide-gene-mediated senescent cell ablation improves pulmonary function and physical health, although lung fibrosis is visibly unaltered, and fibrotic lung disease is mediated, in part, by senescent cells.

TL;DR: Exercise prevents the accumulation of senescent cells and the expression of the SASP while nullifying the damaging effects of the FFD on parameters of health, highlighting a novel mechanism by which exercise mediates its beneficial effects and reinforces the effect of modifiable lifestyle choices on health span.

TL;DR: The circulating SASP may serve as a clinically useful candidate biomarker of age-related health and a powerful tool for interventional human studies and it was showed that SASP proteins were positively associated with age, frailty, and adverse postsurgery outcomes.

TL;DR: The net healthspan benefits afforded by exercise are more favorable than those of TRF, and additional comprehensive studies are warranted before recommending TRF to obese older adults.

TL;DR: The present study revealed that cytochrome P450 enzymes share a strong dynamic similarity (root mean squared inner product and Bhattacharyya coefficient) despite the low sequence identity and sequence similarity across the cyto chrome P450 superfamily.