Koji Iijima

TL;DR: It is demonstrated that early-intervention suicide-gene-mediated senescent cell ablation improves pulmonary function and physical health, although lung fibrosis is visibly unaltered, and fibrotic lung disease is mediated, in part, by senescent cells.

TL;DR: A subset of innate immune cells that responds to IL-33 and vigorously produces Th2-type cytokines is present in mouse lungs, which may provide a novel mechanism for type 2 immunity in the airways and induction of allergic airway diseases such as asthma.

TL;DR: IL-33 and its receptor, ST2, may play important roles in eosinophil-mediated inflammation; they may provide new therapeutic targets for controlling mucosal eOSinophilic inflammation.

TL;DR: Airway exposure of naive mice to a common environmental aeroallergen, the fungus Alternaria alternata, induces rapid release of IL-33 into the airway lumen, followed by innate Th2-type responses, and ATP and purinergic signaling in the respiratory epithelium are critical sensors for airway exposure to airborne allergies.

TL;DR: This work sought to investigate the capacity of ILC2s to regulate effector functions of T cells in innate lymphoid cells and found it to be able to mediate the immune pathology of asthma even without adaptive immunity.