A
Andrew James Godkin
Researcher at Cardiff University
Publications - 126
Citations - 6198
Andrew James Godkin is an academic researcher from Cardiff University. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 39, co-authored 116 publications receiving 5265 citations. Previous affiliations of Andrew James Godkin include University Hospital of Wales & John Radcliffe Hospital.
Papers
More filters
Journal ArticleDOI
Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes
Awen Gallimore,Ann Glithero,Andrew James Godkin,Alain C Tissot,Andreas Plückthun,Tim Elliott,Hans Hengartner,Rolf M. Zinkernagel +7 more
TL;DR: The results of the study show that the outcome of infection by LCMV is determined by antigen load alone, and deletion of virus-specific CTLs in the presence of excessive antigen is preceded by TCR downregulation and is dependent upon perforin.
Journal ArticleDOI
In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope.
TL;DR: Fresh peripheral blood lymphocytes from individual subjects undergoing short-term antigen challenge and tissue transglutaminase-treated, overlapping synthetic peptides spanning A-gliadin are used to demonstrate a transient, disease-specific, DQ2-restricted, CD4 T-cell response to a single dominant epitope.
Journal ArticleDOI
VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium
Dmitry V. Bagaev,Renske M. A. Vroomans,Jerome Samir,Jerome Samir,Ulrik Stervbo,Ulrik Stervbo,Cristina Rius,Garry Dolton,Alexander Greenshields-Watson,Meriem Attaf,Evgeny S. Egorov,Ivan V. Zvyagin,Nina Babel,Nina Babel,David K. Cole,Andrew James Godkin,Andrew K. Sewell,Can Keşmir,Dmitriy M. Chudakov,Fabio Luciani,Fabio Luciani,Mikhail Shugay +21 more
TL;DR: An update of the VDJdb database with a substantial increase in the number of T-cell receptor (TCR) sequences and their cognate antigens and a reduced set of high-quality TCR motifs that can be used for both training TCR specificity predictors and matching against TCRs of interest are reported.
Journal ArticleDOI
CD4+CD25+FOXP3+ Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer
Sarah Louise Clarke,Gareth James Betts,Andrea Plant,Kate Louise Wright,Tariq El-Shanawany,Richard Harrop,Jared Torkington,B. I. Rees,Geraint T. Williams,Awen Gallimore,Andrew James Godkin +10 more
TL;DR: Data demonstrate that Treg capable of inhibiting tumor associated antigen-specific immune responses are enriched in patients with CRC, and support a rationale for manipulating Treg to enhance cancer immunotherapy.
Journal ArticleDOI
Contribution of the MHC region to the familial risk of coeliac disease
Steve Bevan,Sanjay Popat,Christian Braegger,A. Busch,D. O'Donoghue,Karin Fälth-Magnusson,Anne Ferguson,Andrew James Godkin,Lotta Högberg,Geoffrey Holmes,K. B. Hosie,Peter D. Howdle,Herman A. Jenkins,Derek P. Jewell,Stephen R. D. Johnston,Nicholas P. Kennedy,G. D. Kerr,Parveen Kumar,R. F. A. Logan,A. H. G. Love,Michael N. Marsh,Chris J. J. Mulder,Klas Sjöberg,L. Stenhammer,John A. Walker-Smith,A Marossy,Richard S. Houlston +26 more
TL;DR: The MHC genes contribute no more than 40% of the sib familial risk of coeliac disease and the non-HLA linked gene (or genes) are likely to be the stronger determinant of coediac disease susceptibility.