R
Richard S. Houlston
Researcher at Institute of Cancer Research
Publications - 816
Citations - 55450
Richard S. Houlston is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Genome-wide association study & Cancer. The author has an hindex of 110, co-authored 768 publications receiving 50101 citations. Previous affiliations of Richard S. Houlston include University of Southampton & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Systematic Review of Microsatellite Instability and Colorectal Cancer Prognosis
TL;DR: CRCs with MSI have a significantly better prognosis compared to those with intact mismatch repair, and additional studies are needed to further define the benefit of adjuvant chemotherapy in locally advanced tumors with MSI.
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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.
Ian Tomlinson,Alam Na,Andrew Rowan,Ella Barclay,Emma Jaeger,David P. Kelsell,Irene M. Leigh,Gorman P,H. Lamlum,Shamima Rahman,Roylance Rr,Simon E. Olpin,Steve Bevan,Karen Barker,N Hearle,Richard S. Houlston,Maija Ht Kiuru,Rainer Lehtonen,Auli Karhu,Susa Vilkki,Päivi Laiho,Eklund C,Outi Vierimaa,Kristiina Aittomäki,Marja Hietala,Pertti Sistonen,Anders Paetau,Reijo Salovaara,Riitta Herva,Launonen,Lauri A. Aaltonen +30 more
TL;DR: It is shown that a gene that predisposes to multiple fibroids, cutaneous leiomyomata and renal cell carcinoma is mapped to chromosome 1q42, and that this gene encodes fumarate hydratase, an enzyme of the tricarboxylic acid cycle.
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Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
Christopher I. Amos,Xifeng Wu,Peter Broderick,Ivan P. Gorlov,Jian Gu,Timothy Eisen,Qiong Dong,Qing Zhang,Xiangjun Gu,Jayaram Vijayakrishnan,Kate Sullivan,Athena Matakidou,Yufei Wang,Gordon B. Mills,Kimberly F. Doheny,Ya Yu Tsai,Wei Vivien Chen,Sanjay Shete,Margaret R. Spitz,Richard S. Houlston +19 more
TL;DR: Two SNPs, rs1051730 and rs8034191, mapping to a region of strong linkage disequilibrium within 15q25.1 containing PSMA4 and the nicotinic acetylcholine receptor subunit genes CHRNA3 and CHRNA5, were significantly associated with risk in both replication sets.
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Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations
Hanne Meijers-Heijboer,Ans M.W. van den Ouweland,Jan Klijn,Marijke Wasielewski,Anja de Snoo,Rogier A. Oldenburg,Antoinette Hollestelle,M.M.J. Houben,Ellen Crepin,Monique M. van Veghel-Plandsoen,Fons Elstrodt,Cornelia M. van Duijn,C.C.M. Bartels,Carel Meijers,Mieke Schutte,Lesley McGuffog,Deborah J. Thompson,Douglas F. Easton,Nayanta Sodha,Sheila Seal,Rita Barfoot,Jon Mangion,Jenny Chang-Claude,Diana Eccles,Rosalind A. Eeles,D. Gareth Evans,Richard S. Houlston,Victoria Murday,Steven A. Narod,Tamara Peretz,Julian Peto,Julian Peto,Catherine M. Phelan,Hong Xiang Zhang,Csilla Szabo,Peter Devilee,David E. Goldgar,P. Andrew Futreal,Katherine L. Nathanson,Barbara L. Weber,Nazneen Rahman,Michael R. Stratton,Michael R. Stratton +42 more
TL;DR: The biological mechanisms underlying the elevated risk of breast cancer in CHEK2 mutation carriers are already subverted in carriers of BRCA1 or BRCa2 mutations, which is consistent with participation of the encoded proteins in the same pathway.
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Mutations in the SMAD4/DPC4 gene in juvenile polyposis.
James R. Howe,Stina Roth,John C. Ringold,Robert W. Summers,Heikki Järvinen,Pertti Sistonen,Ian Tomlinson,Richard S. Houlston,Steve Bevan,Frank A. Mitros,Edwin M. Stone,Lauri A. Aaltonen +11 more
TL;DR: It is shown that a subset of juvenile polyposis families carry germ line mutations in the gene SMAD4 (also known as DPC4), located on chromosome 18q21.1, that encodes a critical cytoplasmic mediator in the transforming growth factor-beta signaling pathway.