A
Andrew Koff
Researcher at Fred Hutchinson Cancer Research Center
Publications - 16
Citations - 4714
Andrew Koff is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Cyclin E & Cyclin D. The author has an hindex of 9, co-authored 16 publications receiving 4653 citations.
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Journal ArticleDOI
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
Kornelia Polyak,Mong Hong Lee,Hediye Erdjument-Bromage,Andrew Koff,James M. Roberts,Paul Tempst,Joan Massagué +6 more
TL;DR: P27 Kip1 as mentioned in this paper is a cyclin-dependent kinase inhibitor implicated in G1 phase arrest by TGFβ and cell-cell contact, and it has been shown to be highly conserved and broadly expressed in human tissues, and its mRNA levels are similar in proliferating and quiescent cells.
Journal ArticleDOI
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle
Andrew Koff,Antonio Giordano,D Desai,Yamashita K,J. W. Harper,Stephen J. Elledge,Takeharu Nishimoto,David O. Morgan,B. R. Franza,James M. Roberts +9 more
TL;DR: Results provide further evidence that in all eukaryotes assembly of a cyclin-Cdk complex is an important step in the biochemical pathway that controls cell proliferation during G1.
Journal ArticleDOI
Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.
Andrew Koff,Frederick R. Cross,Alfred L. Fisher,Jill M. Schumacher,Katherine Leguellec,Michel Philippe,James M. Roberts +6 more
TL;DR: A new human cyclin, named cyclin E, was isolated by complementation of a triple cln deletion in S. cerevisiae, suggesting that it functioned at START by interacting with the CDC28 protein.
Journal ArticleDOI
Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta
TL;DR: The effects of TGF-beta, which correlated with the inhibition of retinoblastoma protein phosphorylation, suggest that mammalian G1 cyclin-dependent kinases, like their counterparts in yeast, are targets for negative regulators of the cell cycle.