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Andrew Thompson
Researcher at Harvard University
Publications - 13
Citations - 1477
Andrew Thompson is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 11 publications receiving 1208 citations. Previous affiliations of Andrew Thompson include Boston Children's Hospital & University of Maryland, College Park.
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Journal ArticleDOI
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
Won-Suk Chung,Laura E. Clarke,Gordon X. Wang,Benjamin K. Stafford,Alexander Sher,Chandrani Chakraborty,Julia Joung,Lynette C. Foo,Andrew Thompson,Chinfei Chen,Stephen J. Smith,Ben A. Barres +11 more
TL;DR: A novel role for astrocytes in mediating synapse elimination in the developing and adult brain is revealed, MEGF10 and MERTK are identified as critical proteins in the synapse remodelling underlying neural circuit refinement, and have important implications for understanding learning and memory as well as neurological disease processes.
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Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.
Christian Lavedan,Louis Licamele,Simona Volpi,Jennifer Hamilton,Callie Michelle Heaton,Kendra Tomino Mack,Rebecca Lannan,Andrew Thompson,Curt D. Wolfgang,Mihael H. Polymeropoulos +9 more
TL;DR: Results provide new insight into response to iloperidone, developed with the ultimate goal of directing therapy to patients with the highest benefit-to-risk ratio.
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A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation
Shigeki Iwase,Shigeki Iwase,Emily Brookes,Saurabh Agarwal,Aimee I. Badeaux,Hikaru Ito,Christina N Vallianatos,Giulio Srubek Tomassy,Tomas Kasza,Grace Lin,Andrew Thompson,Lei Gu,Kenneth Y. Kwan,Chinfei Chen,Maureen A. Sartor,Brian Egan,Jun Xu,Yang Shi +17 more
TL;DR: It is reported that disruption of the mouse Kdm5c gene recapitulates adaptive and cognitive abnormalities observed in XLID, including impaired social behavior, memory deficits, and aggression, and the findings suggest that loss of KDM5C function may impact gene expression in multiple regulatory pathways relevant to the clinical phenotypes.
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EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction.
Afsane Arvand,Holger Bastians,Scott M. Welford,Andrew Thompson,Joan V. Ruderman,Christopher T. Denny,Christopher T. Denny +6 more
TL;DR: ME2-C, created by changing a catalytic cysteine to serine, inhibits the in vitro ubiquitination and degradation of cyclin B in human HeLa cell extracts, suggesting that part of the biologic effect of EWS/FLI1 could be to transcriptionally modulate genes involved in cell cycle regulation.
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Common effect of antipsychotics on the biosynthesis and regulation of fatty acids and cholesterol supports a key role of lipid homeostasis in schizophrenia
Mihael H. Polymeropoulos,Louis Licamele,Simona Volpi,Kendra Tomino Mack,Shruti N. Mitkus,Eugene D. Carstea,Lise Getoor,Andrew Thompson,Christian Lavedan +8 more
TL;DR: Analysis reveals a common effect of antipsychotics on the biosynthesis and regulation of fatty acids and cholesterol, which is discussed in the context of a lipid hypothesis where alterations in lipid homeostasis might underlie the pathogenesis of schizophrenia.