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Andrew W. Michell
Researcher at University of Cambridge
Publications - 28
Citations - 2504
Andrew W. Michell is an academic researcher from University of Cambridge. The author has contributed to research in topics: Parkinson's disease & Multiple sclerosis. The author has an hindex of 16, co-authored 26 publications receiving 2203 citations.
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Journal ArticleDOI
Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis.
Sarosh R. Irani,Andrew W. Michell,Bethan Lang,Philippa Pettingill,Patrick Waters,Marvin Johnson,Jonathan M. Schott,Richard J. E. Armstrong,Alessandro S. Zagami,Andrew Bleasel,Ernest Somerville,Shelagh M. J. Smith,Angela Vincent,Angela Vincent +13 more
TL;DR: A distinctive seizure semiology is described that closely associates with voltage‐gated potassium channel (VGKC)‐complex/Lgi1 antibodies and commonly precedes the onset of limbic encephalitis (LE).
Journal ArticleDOI
Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study
P Connick,Madhan Kolappan,Charles Crawley,Daniel J. Webber,Rickie Patani,Andrew W. Michell,Ming-Qing Du,Shi-Lu Luan,Daniel R. Altmann,Alan J. Thompson,Alastair Compston,Michael A. Scott,David Miller,Siddharthan Chandran +13 more
TL;DR: In this paper, mesenchymal stem cells were used as a potential neuroprotective treatment for secondary progressive multiple sclerosis (SMS) in 10 patients from the East Anglia and North London regions of the UK.
Journal ArticleDOI
Biomarkers and Parkinson's disease
TL;DR: The current potential biomarkers for Parkinson's disease are discussed, the problems with their use are highlighted, and a discussion of future alternatives are concluded.
Journal ArticleDOI
Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles
Benjamin R. Underwood,David Broadhurst,Warwick B. Dunn,David I. Ellis,Andrew W. Michell,Coralie Vacher,David E. Mosedale,Douglas B. Kell,Roger A. Barker,David J. Grainger,David C. Rubinsztein +10 more
TL;DR: The data raise the prospect of a robust molecular definition of progression of HD prior to symptom onset, and if validated in a genuinely prospective fashion these biomarker trajectories could facilitate the development of useful therapies for this disease.
Journal ArticleDOI
The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments
P Connick,Madhan Kolappan,Rickie Patani,Michael A. Scott,Charles Crawley,Xiao-Ling He,Karen Richardson,Kelly Barber,Daniel J. Webber,Claudia A. M. Wheeler-Kingshott,Daniel J. Tozer,Rebecca S. Samson,David L. Thomas,Ming-Qing Du,Shi L Luan,Andrew W. Michell,Daniel R. Altmann,Alan J. Thompson,David Miller,Alastair Compston,Siddharthan Chandran,Siddharthan Chandran +21 more
TL;DR: The MSCIMS trial tests the safety and feasibility of treatment with a candidate cell-based therapy, and will inform the wider challenge of designing early phase clinical trials to evaluate putative neuroprotective therapies in progressive MS.