R
Rickie Patani
Researcher at Francis Crick Institute
Publications - 107
Citations - 5389
Rickie Patani is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Biology & Induced pluripotent stem cell. The author has an hindex of 28, co-authored 90 publications receiving 4114 citations. Previous affiliations of Rickie Patani include University of Cambridge & Queen Mary University of London.
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Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
James R. Tollervey,Tomaž Curk,Boris Rogelj,Michael Briese,Matteo Cereda,Melis Kayikci,Julian König,Tibor Hortobágyi,Agnes L. Nishimura,Vera Župunski,Vera Župunski,Rickie Patani,Siddharthan Chandran,Gregor Rot,Blaž Zupan,Christopher Shaw,Jernej Ule +16 more
TL;DR: Using individual nucleotide-resolution ultraviolet cross-linking and immunoprecipitation, it is found that TDP-43 preferentially bound long clusters of UG-rich sequences in vivo, highlighting the importance of T DP-43 for the regulation of splicing in the brain.
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Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study
P Connick,Madhan Kolappan,Charles Crawley,Daniel J. Webber,Rickie Patani,Andrew W. Michell,Ming-Qing Du,Shi-Lu Luan,Daniel R. Altmann,Alan J. Thompson,Alastair Compston,Michael A. Scott,David Miller,Siddharthan Chandran +13 more
TL;DR: In this paper, mesenchymal stem cells were used as a potential neuroprotective treatment for secondary progressive multiple sclerosis (SMS) in 10 patients from the East Anglia and North London regions of the UK.
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Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging.
Lilach Soreq,Lilach Soreq,Jamie Rose,Eyal Soreq,John Hardy,Daniah Trabzuni,Mark R. Cookson,Colin Smith,Mina Ryten,Mina Ryten,Rickie Patani,Jernej Ule,Jernej Ule +12 more
TL;DR: Gene expression studies suggest that aging of the human brain is determined by a complex interplay of molecular events, although both its region- and cell-type-specific consequences remain poorly understood.
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Remyelination can be extensive in multiple sclerosis despite a long disease course
TL;DR: Results from this study of two patients with long standing disease suggest that remyelination in MS may be more extensive than previously thought.
Journal ArticleDOI
A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation.
Thomas R. Peskett,Frédérique Rau,Jonathan O’Driscoll,Rickie Patani,Alan R. Lowe,Helen R. Saibil +5 more
TL;DR: It is found that huntingtin exon1 proteins can form reversible liquid-like assemblies, a process driven by huntingtin’s polyQ tract and proline-rich region, and in cells and in vitro, the liquid- like assemblies converted to solid-like assembly with a fibrillar structure.