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Andrey B. Savchenko
Researcher at Salus University
Publications - 13
Citations - 1307
Andrey B. Savchenko is an academic researcher from Salus University. The author has contributed to research in topics: Visual phototransduction & Rhodopsin. The author has an hindex of 13, co-authored 13 publications receiving 1248 citations. Previous affiliations of Andrey B. Savchenko include Scheie Eye Institute & National Institutes of Health.
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Journal ArticleDOI
Massive light-driven translocation of transducin between the two major compartments of rod cells: A novel mechanism of light adaptation
Maxim Sokolov,Arkady Lyubarsky,Katherine J. Strissel,Andrey B. Savchenko,Viktor I. Govardovskii,Edward N. Pugh,Vadim Y. Arshavsky +6 more
TL;DR: A novel technique that combines serial tangential cryodissection of the rat retina with Western blot analysis of protein distribution in the sections is developed, allowing rods to operate in illumination up to 10-fold higher than would otherwise be possible.
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In Utero Gene Therapy Rescues Vision in a Murine Model of Congenital Blindness
Nadine S. Dejneka,Enrico Maria Surace,Tomas S. Aleman,Artur V. Cideciyan,Arkady Lyubarsky,Andrey B. Savchenko,T. Michael Redmond,Waixing Tang,Zhangyong Wei,Tonia S. Rex,Ernest Glover,Albert M. Maguire,Edward N. Pugh,Samuel G. Jacobson,Jean Bennett +14 more
TL;DR: In utero delivery of the human RPE65 cDNA to retinal pigment epithelium cells in a murine model of LCA is determined and AAV-mediated correction of the deficit is demonstrated and suggested that in utero retinal gene delivery may be a useful approach for treating a variety of blinding congenital retinal diseases.
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Light Response of Retinal ON Bipolar Cells Requires a Specific Splice Variant of Gαo
Anuradha Dhingra,Meisheng Jiang,Tian Li Wang,Arkady Lyubarsky,Andrey B. Savchenko,Tehilla Bar-Yehuda,Peter Sterling,Lutz Birnbaumer,Noga Vardi +8 more
TL;DR: Electroretinography performed on mice deficient for one splice variant or the other shows that the positive b-wave (response of ON bipolar cells to rod and cone input) requires αo1 but not αo2, so the light response of the ON bipolar cell is probably carried by its strongly expressed splICE variant, Gαo1.
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A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival.
Amir Rattner,Philip M. Smallwood,John Williams,Carol A. Cooke,Andrey B. Savchenko,Arkady Lyubarsky,Edward N. Pugh,Jeremy Nathans +7 more
TL;DR: A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing and suggests that localized adhesion activity is essential for outer segment integrity.
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The Y99C mutation in guanylyl cyclase-activating protein 1 increases intracellular Ca2+ and causes photoreceptor degeneration in transgenic mice.
Elena V. Olshevskaya,Peter D. Calvert,Michael L. Woodruff,Igor V. Peshenko,Andrey B. Savchenko,Clint L. Makino,Ye-Shih Ho,Gordon L. Fain,Alexander M. Dizhoor +8 more
TL;DR: These results provide the first direct evidence that a mutation linked to congenital blindness increases Ca2+ in the outer segment, which may trigger the apoptotic process.