M
Michael L. Woodruff
Researcher at University of California, Los Angeles
Publications - 54
Citations - 2042
Michael L. Woodruff is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Rhodopsin & Visual phototransduction. The author has an hindex of 27, co-authored 50 publications receiving 1880 citations. Previous affiliations of Michael L. Woodruff include Jules Stein Eye Institute.
Papers
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Journal ArticleDOI
Measurement of cytoplasmic calcium concentration in the rods of wild-type and transducin knock-out mice
Michael L. Woodruff,Alapakkam P. Sampath,Hugh R. Matthews,N. V. Krasnoperova,Janis Lem,Gordon L. Fain +5 more
TL;DR: Rods from transducin α‐subunit knock‐out (Trα–/–) animals showed no light‐dependent decline in fluorescence but exhibited an initial rapid component of fluorescence increase which could be fitted with a single exponential (τ∼1–4 ms).
Journal ArticleDOI
Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis.
Michael L. Woodruff,Zhongyan Wang,Hae Yun Chung,T. Michael Redmond,Gordon L. Fain,Janis Lem,Janis Lem +6 more
TL;DR: It is shown that activation of sensory transduction by unliganded opsin, and not the accumulation of retinyl esters, causes light-independent retinal degeneration in LCA, and a similar mechanism may also be responsible for degeneration induced by vitamin A deprivation.
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AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase
Xiaoqing Liu,O. V. Bulgakov,Xiao Hong Wen,Michael L. Woodruff,Basil S. Pawlyk,Jun Yang,Gordon L. Fain,Michael A. Sandberg,Clint L. Makino,Tiansen Li +9 more
TL;DR: It is suggested that AIPL1 is a specialized chaperone required for rod PDE biosynthesis, a condition that phenocopies retinal degenerations in the rd mouse and in a subgroup of human patients.
Journal ArticleDOI
Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3.
Dean Bok,Gary C. Galbraith,Ivan A. Lopez,Michael L. Woodruff,Steven Nusinowitz,Hector BeltrandelRio,Wenhu Huang,Shulei Zhao,Robert S. Geske,Charles A. Montgomery,Isaac Van Sligtenhorst,Carl Friddle,Kenneth A. Platt,Mary Jean Sparks,Alexander Pushkin,Natalia Abuladze,Akira Ishiyama,Ramanath Dukkipati,Weixin Liu,Ira Kurtz +19 more
TL;DR: The results indicate that in certain sensory organs, in which the requirement to transduce specific environmental signals with speed, sensitivity and reliability is paramount, the choice of the H+ disposal mechanism used is limited.
Journal ArticleDOI
The Y99C mutation in guanylyl cyclase-activating protein 1 increases intracellular Ca2+ and causes photoreceptor degeneration in transgenic mice.
Elena V. Olshevskaya,Peter D. Calvert,Michael L. Woodruff,Igor V. Peshenko,Andrey B. Savchenko,Clint L. Makino,Ye-Shih Ho,Gordon L. Fain,Alexander M. Dizhoor +8 more
TL;DR: These results provide the first direct evidence that a mutation linked to congenital blindness increases Ca2+ in the outer segment, which may trigger the apoptotic process.