J
Jeremy Nathans
Researcher at Johns Hopkins University School of Medicine
Publications - Â 230
Citations - Â 35238
Jeremy Nathans is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Frizzled & Wnt signaling pathway. The author has an hindex of 94, co-authored 225 publications receiving 32937 citations. Previous affiliations of Jeremy Nathans include Massachusetts Institute of Technology & University of Miami.
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A new member of the frizzled family from Drosophila functions as a Wingless receptor.
Purnima Bhanot,Marcel Brink,Cindy Harryman Samos,Jen Chih Hsieh,Yanshu Wang,Jennifer P. Macke,Deborah J. Andrew,Jeremy Nathans,Roel Nusse +8 more
TL;DR: It is shown that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein, implying that Frizzled proteins are receptors for the Wnt signalling molecules.
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Molecular genetics of human color vision: the genes encoding blue, green, and red pigments
TL;DR: The isolation and sequencing of genomic and complementary DNA clones that encode the apoproteins of these three pigments are described and the deduced amino acid sequences show 41 +/- 1 percent identity with rhodopsin.
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A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy
Rando Allikmets,Nanda A. Singh,Hui Sun,Noah F. Shroyer,Amy Hutchinson,Abirami Chidambaram,Bernard Gerrard,Lisa Baird,Dora Stauffer,Andy Peiffer,Amir Rattner,Philip M. Smallwood,Yixin Li,Kent L. Anderson,Richard A. Lewis,Jeremy Nathans,Mark Leppert,Michael Dean,James R. Lupski +18 more
TL;DR: Mutational analysis of ABCR in STGD families revealed a total of 19 different mutations including homozygous mutations in two families with consanguineous parentage, indicating that ABCR is the causal gene of STGD/FFM.
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Vascular development in the retina and inner ear: Control by Norrin and frizzled-4, a high-affinity ligand-receptor pair
Qiang Xu,Yanshu Wang,Alain Dabdoub,Philip M. Smallwood,John Williams,Chad Woods,Matthew W. Kelley,Li Jiang,William Tasman,Kang Zhang,Jeremy Nathans +10 more
TL;DR: It is shown that Norrin and Fz4 function as a ligand-receptor pair that plays a central role in vascular development in the eye and ear, and it is indicated that ligands unrelated to Wnts can act through Fz receptors.
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A new secreted protein that binds to Wnt proteins and inhibits their activites
Jen Chih Hsieh,Laurent Kodjabachian,Martha L. Rebbert,Amir Rattner,Philip M. Smallwood,Cindy Harryman Samos,Roel Nusse,Igor B. Dawid,Jeremy Nathans +8 more
TL;DR: Wnt-inhibitory factor-1 (WIF-1) is described, a secreted protein that binds to Wnt proteins and inhibits their activities, and results indicate that WNT proteins interact with structurally diverse extracellular inhibitors to fine-tune the spatial and temporal patterns of Wnt activity.