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Andrey S. Shaw
Researcher at Genentech
Publications - 217
Citations - 28902
Andrey S. Shaw is an academic researcher from Genentech. The author has contributed to research in topics: T cell & T-cell receptor. The author has an hindex of 83, co-authored 216 publications receiving 27329 citations. Previous affiliations of Andrey S. Shaw include Yale University & Yeshiva University.
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Journal ArticleDOI
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
Journal ArticleDOI
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.
TL;DR: Results indicate that serine-216 phosphorylation and 14-3-3 binding negatively regulate Cdc25C and identify CDC25C as a potential target of checkpoint control in human cells.
Journal ArticleDOI
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine.
TL;DR: The results suggest that the interactions of 14-3-3 with signaling proteins are critical for the activation of signaling proteins and suggest novel roles for serine/threonine phosphorylation in the assembly of protein-protein complexes.
Journal ArticleDOI
The immunological synapse.
Shannon K. Bromley,W R Burack,Kenneth G. Johnson,Kristina Somersalo,Tasha N. Sims,C Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +9 more
TL;DR: The current model is that signaling and formation of the immunological synapse are tightly interwoven in mature T cells and this model is extended to natural killer cell activation, where the inhibitory NK synapse provides a striking example in which inhibition of signaling leaves the synapse in its nascent, inverted state.
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Congenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein
Neng-Yao Shih,Jun Li,Vladimir Karpitskii,Ancho Nguyen,Michael L. Dustin,Osami Kanagawa,Jeffrey H. Miner,Andrey S. Shaw +7 more
TL;DR: Supporting a role for CD2 AP in the specialized cell junction known as the slit diaphragm, CD2AP associated with nephrin, the primary component of the slitdiaphragms, is supported.