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Andrzej Stasiak
Researcher at Swiss Institute of Bioinformatics
Publications - 205
Citations - 13819
Andrzej Stasiak is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: DNA & DNA supercoil. The author has an hindex of 60, co-authored 202 publications receiving 13083 citations. Previous affiliations of Andrzej Stasiak include Polish Academy of Sciences & ETH Zurich.
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Journal ArticleDOI
Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.
Adelina A. Davies,Jean-Yves Masson,Michael J. McIlwraith,Alicja Z. Stasiak,Andrzej Stasiak,Ashok R. Venkitaraman,Stephen C. West +6 more
TL;DR: It is shown that BRCA2 plays a dual role in regulating the actions of RAD51, a protein essential for homologous recombination and DNA repair, which may be a key event leading to genomic instability and tumorigenesis in patients predisposed to breast and ovarian cancers.
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Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA.
TL;DR: Using a topological assay, it is demonstrated that hRad51 underwinds duplex DNA, in a reaction dependent upon the presence of ATP or its non‐hydrolysable analogue ATP gamma S.A.
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Geometry and physics of knots
Vsevolod Katritch,Vsevolod Katritch,Jan Bednar,Jan Bednar,Didier Michoud,Robert G. Scharein,Jacques Dubochet,Andrzej Stasiak +7 more
TL;DR: In this article, the authors considered the properties of particular geometrical forms which they define as "ideal" for a knot with a given topology and assembled from a tube of uniform diameter.
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Identification and purification of two distinct complexes containing the five RAD51 paralogs.
Jean-Yves Masson,Madalena Tarsounas,Alicja Z. Stasiak,Andrzej Stasiak,Rajvee Shah,Michael J. McIlwraith,Fiona E. Benson,Stephen C. West +7 more
TL;DR: It is suggested that the extreme sensitivity of paralog-defective cell lines to cross-linking agents is owing to defects in the processing of incised cross links and the consequential failure to initiate recombinational repair at these sites.
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Role of RecA protein spiral filaments in genetic recombination.
TL;DR: Physical and enzymatic studies on RecA protein from Escherichia coli provide the basis for a molecular model of general genetic recombination, a novel feature of which is the role attributed to spiral filaments of RecAprotein.