Aneesa Sultan

TL;DR: The data show that ZEB1 represents a key player in pathologic EMTs associated with tumour progression, and downregulation in undifferentiated cancer cells by RNA interference was sufficient to upregulate expression of cell polarity genes on the RNA and protein level, to re-establish epithelial features and to impair cell motility in vitro.

TL;DR: It is described that the EMT-inducing transcriptional repressor ZEB1 promotes colorectal cancer cell metastasis and loss of cell polarity and shows that retention of Lgl2 expression is critical for the epithelial phenotype and that its loss might be involved in metastasis.

TL;DR: It is reported that PKP3 is transcriptionally repressed by the E‐cadherin repressor ZEB1 in metastatic cancer cells and contributes to Z EB1‐mediated disintegration of intercellular adhesion and epithelial to mesenchymal transition.

TL;DR: It is concluded that biosurfactant production is influenced by the availability of nutrients, which can be enhanced with the use of biosurFactant producing bacteria.

TL;DR: A deeper understanding of ovarian cancer-derived EVs, the types of cargo molecules and their biological roles in cancer growth, metastases and drug resistance, could have significant impact on the discovery of novel biomarkers and innovative therapeutics.