Roland Foisner

TL;DR: RNA interference-mediated downregulation of deltaEF1 in cancer cells was sufficient to derepress E-cadherin expression and restore cell to cell adhesion, suggesting that deltaEF 1 is a key player in late stage carcinogenesis.

TL;DR: Myoblast transcriptome analyses indicated that selective disruption of the LBR- or lamin-A-dependent heterochromatin tethers have opposite effects on muscle gene expression, either increasing or decreasing, respectively.

TL;DR: The data show that ZEB1 represents a key player in pathologic EMTs associated with tumour progression, and downregulation in undifferentiated cancer cells by RNA interference was sufficient to upregulate expression of cell polarity genes on the RNA and protein level, to re-establish epithelial features and to impair cell motility in vitro.

TL;DR: It is demonstrated that the transfection activity of the DNA complex can be increased by addition of free polycation as long as a sufficient quantity of polycation-transferrin conjugates remains in the complex to ensure its binding to the cellular receptor.

TL;DR: Using in vitro assays, it is suggested that LAP 2 may have a key role in initial events of nuclear envelope reassembly, and that both LAP2 and LAP 1 may be involved in attaching lamins to the nuclear envelope.