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Angela M. Kloepfer
Researcher at Broad Institute
Publications - 1
Citations - 1760
Angela M. Kloepfer is an academic researcher from Broad Institute. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 1, co-authored 1 publications receiving 1630 citations.
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A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen
Jason Moffat,Dorre A. Grueneberg,Xiaoping Yang,So Young Kim,So Young Kim,Angela M. Kloepfer,Gregory Hinkle,Gregory Hinkle,Bruno Piqani,Thomas Eisenhaure,Biao Luo,Jennifer K. Grenier,Anne E. Carpenter,Shi Yin Foo,Sheila A. Stewart,Brent R. Stockwell,Nir Hacohen,Nir Hacohen,William C. Hahn,William C. Hahn,Eric S. Lander,David M. Sabatini,David M. Sabatini,David E. Root +23 more
TL;DR: A screen based on high-content imaging was developed to identify genes required for mitotic progression in human cancer cells and applied to an arrayed set of 5,000 unique shRNA-expressing lentiviruses that target 1,028 human genes, providing a widely applicable resource for loss-of-function screens.