Angela Maria da Silva

TL;DR: Proinflammatory cytokines and immune complexes with low Th2 responses might explain the immunopathogenesis of acute schistosomiasis.

TL;DR: A role for type 2 cytokines in hepatic fibrosis in human schistosomiasis mansoni is suggested, particularly in subjects who remained untreated for 1 year following initial assessment and developed more serious fibrosis during this period.

TL;DR: The data argue that HO-1 has a critical role in the L. chagasi infection and is strongly associated with the inflammatory imbalance during VL, which could serve as an adjunctive therapeutic approach.

TL;DR: Test the hypothesis that the immune profile of individuals infected with Leishmania (L.) infantum is associated with the development and severity of disease and suggest the direct participation of sCD14 in the activation of the immune response against L. infantum, which reinforces the close relationship of IFN-γ,IL-10, IL-6, TNF-α and IL-27 in the immune dynamics of VL.

TL;DR: Through whole-genome sequencing analysis, non-Leishmania parasites isolated from a man with a fatal visceral leishmaniasis–like illness in Brazil were identified and infected mice and reproduced the patient’s clinical manifestations.