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Angélica González-Maciel
Publications - 56
Citations - 3199
Angélica González-Maciel is an academic researcher. The author has contributed to research in topics: Population & Oxidative stress. The author has an hindex of 19, co-authored 53 publications receiving 2491 citations.
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Journal ArticleDOI
Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults:
Lilian Calderón-Garcidueñas,Anna C. Solt,Carlos Henríquez-Roldán,Ricardo Torres-Jardón,Bryan Nuse,Lou Herritt,Rafael Villarreal-Calderon,Norma Osnaya,Ida M. Stone,Raquel Garcia,Diane M. Brooks,Angélica González-Maciel,Rafael Reynoso-Robles,Ricardo Delgado-Chávez,William Reed +14 more
TL;DR: Air pollution causes neuroinflammation, an altered brain innate immune response, and accumulation of Aβ42 and α-synuclein starting in childhood, and carriers of the APOE 4 allele could have a higher risk of developing Alzheimer’s disease if they reside in a polluted environment.
Journal ArticleDOI
Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs.
Lilian Calderón-Garcidueñas,Antonieta Mora-Tiscareño,Esperanza Ontiveros,Gilberto Gómez-Garza,Gerardo Barragán-Mejía,James M. Broadway,Susan Chapman,Gildardo Valencia-Salazar,Valerie Jewells,Robert R. Maronpot,Carlos Henríquez-Roldán,Beatriz Pérez-Guillé,Ricardo Torres-Jardón,Lou Herrit,Diane M. Brooks,Norma Osnaya-Brizuela,Maria E. Monroy,Angélica González-Maciel,Rafael Reynoso-Robles,Rafael Villarreal-Calderon,Anna C. Solt,Randall W. Engle +21 more
TL;DR: The present work presents a groundbreaking, interdisciplinary methodology for addressing relationships between environmental pollution, structural brain alterations by MRI, and cognitive deficits/delays in healthy children.
Journal ArticleDOI
Urban air pollution: influences on olfactory function and pathology in exposed children and young adults.
Lilian Calderón-Garcidueñas,Maricela Franco-Lira,Carlos Henríquez-Roldán,Norma Osnaya,Angélica González-Maciel,Rafael Reynoso-Robles,Rafael Villarreal-Calderon,Lou Herritt,Diane M. Brooks,Sheyla Keefe,Juan Palacios-Moreno,Rodolfo Villarreal-Calderon,Ricardo Torres-Jardón,Humberto Medina-Cortina,Ricardo Delgado-Chávez,Mario Aiello-Mora,Robert R. Maronpot,Richard L. Doty +17 more
TL;DR: In this article, the authors compared the olfactory function of individuals living under conditions of extreme air pollution to that of controls from a relatively clean environment and explore associations between olfaction scores, apolipoprotein E (APOE) status, and pollution exposure.
Journal ArticleDOI
Neuroinflammation, Hyperphosphorylated Tau, Diffuse Amyloid Plaques, and Down-Regulation of the Cellular Prion Protein in Air Pollution Exposed Children and Young Adults
Lilian Calderón-Garcidueas,Michael P. Kavanaugh,Michelle L. Block,Amedeo D'Angiulli,Ricardo Delgado-Chávez,Ricardo Torres-Jardón,Angélica González-Maciel,Rafael Reynoso-Robles,Norma Osnaya,Rodolfo Villarreal-Calderon,Ruixin Guo,Zhaowei Hua,Hongtu Zhu,George Perry,Philippe Diaz +14 more
TL;DR: A role for air pollution in CNS damage and its impact upon the developing brain and the potential etiology of AD and mood disorders is supported.
Journal ArticleDOI
Pediatric Respiratory and Systemic Effects of Chronic Air Pollution Exposure : Nose, Lung, Heart, and Brain Pathology
Lilian Calderón-Garcidueñas,Maricela Franco-Lira,Ricardo Torres-Jardón,Carlos Henríquez-Roldán,Gerardo Barragán-Mejía,Gildardo Valencia-Salazar,Angélica González-Maciel,Rafael Reynoso-Robles,Rafael Villarreal-Calderon,William Reed +9 more
TL;DR: The findings of nasal barrier disruption, systemic inflammation, and the upregulation of COX2 and IL-1β expression and Aβ42 accumulation in brain suggests that sustained exposures to significant concentrations of air pollutants such as particulate matter could be a risk factor for AD and other neurodegenerative diseases.