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Ida M. Stone
Researcher at University of Montana
Publications - 7
Citations - 887
Ida M. Stone is an academic researcher from University of Montana. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 5, co-authored 7 publications receiving 761 citations.
Papers
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Journal ArticleDOI
Long-term Air Pollution Exposure Is Associated with Neuroinflammation, an Altered Innate Immune Response, Disruption of the Blood-Brain Barrier, Ultrafine Particulate Deposition, and Accumulation of Amyloid β-42 and α-Synuclein in Children and Young Adults:
Lilian Calderón-Garcidueñas,Anna C. Solt,Carlos Henríquez-Roldán,Ricardo Torres-Jardón,Bryan Nuse,Lou Herritt,Rafael Villarreal-Calderon,Norma Osnaya,Ida M. Stone,Raquel Garcia,Diane M. Brooks,Angélica González-Maciel,Rafael Reynoso-Robles,Ricardo Delgado-Chávez,William Reed +14 more
TL;DR: Air pollution causes neuroinflammation, an altered brain innate immune response, and accumulation of Aβ42 and α-synuclein starting in childhood, and carriers of the APOE 4 allele could have a higher risk of developing Alzheimer’s disease if they reside in a polluted environment.
Journal ArticleDOI
Adeno-associated virus-mediated gene transfer to hair cells and support cells of the murine cochlea.
TL;DR: Using AAV vectors and specific promoters, cell-type-specific expression of transgenes can be established within the cochlea through transducing cochlear hair cells and support cells.
Journal ArticleDOI
Selective overexpression of excitatory amino acid transporter 2 (EAAT2) in astrocytes enhances neuroprotection from moderate but not severe hypoxia–ischemia
TL;DR: Results indicate that functional EAAT2 can be selectively overexpressed in astrocytes, leading to enhanced neuroprotection, but this cell type specific increase in EAAT1 expression offers only limited protection compared to treatment with penicillin-G.
Journal ArticleDOI
Over-expression of the human EAAT2 glutamate transporter within neurons of mouse organotypic hippocampal slice cultures leads to increased vulnerability of CA1 pyramidal cells.
Julie V. Selkirk,Theodore H. Stiefel,Ida M. Stone,Greg S. Naeve,Alan C. Foster,David J. Poulsen +5 more
TL;DR: A significant increase in CA1 neuronal damage was observed in slices over‐expressing EAAT2 in neurons following an acute exposure to exogenous glutamate, suggesting that the increased expression ofEAAT2 within neurons may contribute to neurodegeneration.
Patent
Aav mediated gene delivery to cochlear cells
TL;DR: In this article, the authors proposed a method of transducing mammalian cochlear cells, more preferably, co-lear hair cells and support cells, which involves the delivery of adeno-associated virus (AAV) to a target mammalian Cochlear cell.