J. Appl. Cryst.の発刊に際して

https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

The biaryl structural motif is a predominant feature in many pharmaceutically relevant and biologically active compounds. As a result, for over a century 1 organic chemists have sought to develop new and more efficient aryl -aryl bond-forming methods. Although there exist a variety of routes for the construction of aryl -aryl bonds, arguably the most common method is through the use of transition-metalmediated reactions. 2-4 While earlier reports focused on the use of stoichiometric quantities of a transition metal to carry out the desired transformation, modern methods of transitionmetal-catalyzed aryl -aryl coupling have focused on the development of high-yielding reactions achieved with excellent selectivity and high functional group tolerance under mild reaction conditions. Typically, these reactions involve either the coupling of an aryl halide or pseudohalide with an organometallic reagent (Scheme 1), or the homocoupling of two aryl halides or two organometallic reagents. Although a number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps. In particular, the obligation to use coupling partners that are both activated is wasteful since it necessitates the installation and then subsequent disposal of stoichiometric activating agents. Furthermore, preparation of preactivated aryl substrates often requires several steps, which in itself can be a time-consuming and economically inefficient process.

http://aether.cmi.ua.ac.be/artikels/Artikels%20Gitte/Artikels/Reviews/Heck-Type-lautens.pdf

Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.

Click Chemistry for Drug Development and Diverse Chemical–Biology Applications

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

OXIDATION OF BORNEOL TO CAMPHOR WITH BLEACH: A SIMPLE, GREEN CHEMISTRY AND INEXPENSIVE EXPERIMENT. Regulatory pressure is increasingly focusing on the use and disposal of substances hazardous to human health and environment. In the last years efforts have also been made to introduce green chemistry concepts in undergraduate courses. In this paper we present an experiment on the oxidation reaction of borneol to camphor with bleach in acetone. This experiment is important to show undergraduate students that a cheap and non hazardous commercial product can be a useful oxidation agent of alcohols.Keywords: oxidation; borneol; bleach.

Oxidação do borneol à cânfora com água sanitária - um experimento simples, de baixo

Solid-state 13C NMR and molecular modeling studies of acetyl aleuritolic acid obtained from Croton cajucara Benth

Isatin halogen-derivatives redox behaviour

Vellozone, a tetracyclic triterpene from Vellozia stipitata☆

Tuberculosis is a serious public health problem, especially in underdeveloped or developing countries. The first line antiTB treatment was developed more than 40 years ago, and this, in addition to the development of strains of Mycobacterium tuberculosis resistant to multiple drugs and co-infection with the AIDS virus, has worsened the situation of this disease worldwide. The urgent need for new drugs active against multidrug-resistant strains and capable for concurrently use with drugs for AIDS treatment has led to efforts by pharmaceutical industries and governmental and nongovernmental organizations to develop these substances. This review describes the process of developing new antiTB drugs and the chemistry of new molecules drug candidates that are in clinical trials for this disease listed in the global portfolio of Stop TB Partnership.  DOI: 10.5935/1984-6835.20120023

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Angelo C. Pinto

Papers

Oxidação do borneol à cânfora com água sanitária - um experimento simples, de baixo

Solid-state 13C NMR and molecular modeling studies of acetyl aleuritolic acid obtained from Croton cajucara Benth

Isatin halogen-derivatives redox behaviour

Vellozone, a tetracyclic triterpene from Vellozia stipitata☆

A Química Medicinal de Novas Moléculas em Fase Clínica para o Tratamento da Tuberculose